Latest technologies from MUSC Foundation for Research Developmenthttp://musc.technologypublisher.comBe the first to know about the latest inventions and technologies available from MUSC Foundation for Research Developmenten-USTue, 20 Mar 2018 00:28:24 GMTMon, 19 Mar 2018 12:40:18 GMT 2018, MUSC Foundation for Research DevelopmentBiopsy Clip Metal Detector to Aid Breast Surgery, 19 Mar 2018 12:40:18 GMTtechnology@musc.edu Preconditioning with Mitochondrial Elongating Agents M1/Mdivi1 in Transplantation, 19 Mar 2018 08:20:53 GMTtechnology@musc.edu Telemedicine Optimized Burn Intervention experts in pediatric burn care, health communication, nursing, public health, biostatistics, information technology, and clinical psychology have developed a mobile application (TOBI) that allows for tertiary clinical burn care in the home by connecting patients and families with expert burn nurses and physicians. The app enables burn physicians and nurses the ability to monitor and intervene during the injury assessment and wound care phase of the treatment of a serious burn. Based upon how the wound healing is progressing, the burn nurse will send encouraging text messages noting burn h...Thu, 04 Jan 2018 14:32:24 GMTtechnology@musc.edu of target protein distribution detection in normal and disease-associated protein in thin tissue sections, 04 Jan 2018 07:21:10 GMTtechnology@musc.edu Wound Healing Matrix researchers have invented a multi-layered system designed to reduce healing time of difficult to heal wounds such as enterocutaneous and enteroatmospheric fistulas, pressure ulcers, diabetic wounds, among others. This multilayer and multifaceted smart wound dressing (SWOD) device addresses many of the limitations of current wound healing strategies: it provides a unidirectional fluid flux barrier layer for wound fluid to egress, an antibacterial layer, induces neovascularization, and reduces the inflammatory response via purinergic signaling blockade to promote and accelerate the healing ...Mon, 27 Nov 2017 12:57:43 GMTtechnology@musc.edu for Cyroprotectant Tissues Perfusion and Bioengineered Tissue Scaffolds, 06 Nov 2017 09:53:28 GMTtechnology@musc.edu Gene Variants Predict Response to Aripiprazole in Individuals, 13 Oct 2017 11:59:25 GMTtechnology@musc.edu Combination of Two Genetic Variants Can Predict Response to Naltrexone in Individuals with Alcohol Use Disorder (AUD) Researchers at MUSC have identified multiple gene variants that are critical for the response to opioid receptor antagonists, including naltrexone for AUD. First, recent work has further validated that carriers of OPRM1 asp40/ DAT10 variable number tandem repeat (VNTR) and asn40/ DAT9 variant carriers do better on naltrexone than other treatment groups (figure 1). These results suggest an epistatic balance of the opioid and dopamine systems may exist that should be taken into account in AUD trials.In addition, a single nucleotide polymorphism (SNP) in another functional gene that c...Fri, 13 Oct 2017 09:40:48 GMTtechnology@musc.edu Array of Multi-substrate Cell Migration Assay (LAMA) The invention is a cell migration chamber that allows for multiple substrates to be used in a single assay. The system uses parallel tracks of different substrates and a gap migration technique. This system and method allows for cell adhesion, migration and differentiation on up to 20 different test conditions simultaneously using only minute amounts of target substrata. This system has two configurations for direct comparison of one or two cell type in response to an array of ECM constituents in the same culture conditions. This culture model could also be used for high throughput...Mon, 09 Oct 2017 12:05:20 GMTtechnology@musc.edu Body Irradiation Using Pre-Existing Dose Dynamic Fields TA library of pre-commissioned dose dynamic fields offers a simple method for delivery of total body irradiation (TBI) given in preparation for transplant. This simple technique is available for any VMAT-capable machine, regardless of the treatment room size or span of the MLCs, yet does not require complex planning or patient-specific MLC patterns. Unlike other similar TBI techniques that require whole-body CT scans, this technique can use simple measurements of patient size for treatment planning. The researchers have generated four pre-defined dose dynamic arcs that can produce ...Mon, 09 Oct 2017 05:32:09 GMTtechnology@musc.edu Peptide Inhibitors of Lysine-Specific Demethylase 1- Sickle Cell Disease, 13 Sep 2017 08:24:46 GMTtechnology@musc.edu targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs), 22 Aug 2017 05:13:30 GMTtechnology@musc.edu Modified T cells for Adoptive Cell Therapy Against Cancer, 10 Jul 2017 08:25:00 GMTtechnology@musc.edu effects of oxetanyl sulfoxides Currently, there are only two approved therapies for Idiopathic Pulmonary Fibrosis (IPF), pirfenidone and nintedanib, which are minimally effective at slowing the disease. These treatments are not effective at all in halting or reversing the progression of IPF. Therefore, there remains a great need for more effective therapies. Researchers at MUSC and Pitt have found that a novel compound, MMS-350, can significantly reduce pro-fibrotic factors and ECM proteins both in vitro and in vivo. Figure 1 demonstrates that in bleomycin treated mice oral doses of MMS-350 ameliorates fibrosis ...Wed, 14 Jun 2017 13:07:25 GMTtechnology@musc.edu Surgical Drainage System, 07 Jun 2017 11:12:33 GMTtechnology@musc.edu - E-Learning Mobile Application in the Use of Ambulatory Assistive Devices, 24 May 2017 10:10:07 GMTtechnology@musc.edu<![CDATA[Electrobiome®: Microbial Production of Chemicals & Fuels from CO¬2]]>, 22 May 2017 09:43:30 GMTtechnology@musc.edu of chemotherapeutics to brain tumors Brain cancer is a life-threatening disease with a poor prognosis. This includes Glioblastoma Multiform (GBM), which has a standard treatment of surgical resection, radiation therapy and concurrent chemotherapy with temozolomide (TMZ). The median survival is 14 months because surgeons are unable to completely remove GBM, radiation does not completely eradicate the tumor tissue and TMZ dosing is limited by toxicity. At standard of care doses, hematologic toxicity of administered TMZ is dose limiting, implying that an increased intratumoral concentration of TMZ could be beneficial to ...Thu, 18 May 2017 08:16:34 GMTtechnology@musc.edu bioluminescent probe (YuLu) for the detection of luciferase global preclinical imaging market is estimated to reach 910 million in the US alone by 2021, including utilizing bioluminescent probes to study biological processes in vitro and in vivo in real time, image cancer cells, monitor gene delivery and adoptively transferred cells and track pathogen clearance, detect apoptosis and research signal transduction. Current limitations with many bioluminescence probes are the need for an external light source to excite the probe. Lucerifase based probes overcome this issue, however, D-luciferin or other small molecule substrates only last a very short ...Wed, 17 May 2017 07:20:54 GMTtechnology@musc.edu mediated metabolic axis in anti-tumor T cell immunotherapy, 12 May 2017 10:17:49 GMTtechnology@musc.edu Matrix: A Novel Cloud-Based System for Tracking Non-RVU Value-Added Work Metrics Matrix is a novel cloud based system used to track value-added non-RVU (vRVU) work metrics with minimal interruption to the radiologist workflow. The password- protected home page for the system contains links to web based forms created using Google Forms, with collected data populating Google Sheets spreadsheets. vRVU metrics initially selected for tracking included time spent at or in preparation for interdisciplinary conferences, time spent on hospital committee meetings, time spent reviewing outside studies (not billed at our institution), and time spent on practice based quality im...Fri, 14 Apr 2017 12:10:35 GMTtechnology@musc.edu Tumor Suppression Effects of Cisplatin Utilizing a HPV Derived Peptide for Head and Neck Cancers Inventors found that human papillomavirus (HPV) activates a specific protein called E2F5 to improve cell death in HPV (+) head and neck squamous cell carcinoma (HNSCC) cells and tumors in culture and in animals. Using molecular, pharmacologic and genetic tools, the inventors have shown that HPV early protein 7 (E7) enhances ceramide-mediated lethal mitophagy in response to chemotherapy-induced cellular stress in HPV-positive HNSCC cells by selectively targeting retinoblastoma protein (RB). Inhibition of RB by HPV-E7 relieves E2F5, which then associates with DRP1, providing a scaffo...Tue, 11 Apr 2017 12:18:34 GMTtechnology@musc.edu Protein Inhibitors as Fetal Hemoglobin Inducers for Sickle Cell Disease at MUSC have identified several potential inhibitors of lysine-specific demethylase 1 (LSD1) utilizing a virtual screen, and found compounds that fit the LSD1 active site in silico. Researchers have synthesized these molecules and evaluated them as LSD1 inhibitors, and several compounds inhibit the enzyme with Ki values in the mid-to upper nanomolar range. The series of compounds are new chemical entities and are being developed by structural modification into lead compounds with the goal of developing them as antitumor agents as well as exploring them for sickle cell disease with ...Tue, 04 Apr 2017 04:58:58 GMTtechnology@musc.edu of GARP antibodies and fusion proteins in cancer, inflammatory and immune conditions at MUSC have demonstrated that GARP is a novel oncogene due to its cancer-intrinsic roles in promoting invasion and metastasis, as well as its cancer-extrinsic roles in inducing immune tolerance. Administration of a GARP-specific mAb limited metastasis and resulted in an effective cancer therapy in a mouse model of breast cancer (Fig 1). Multiple antibodies and fusion proteins for modulating levels of GARP have been generated and may be useful in treating cancer, acute graft-versus-host disease, transplant rejection, inflammatory conditions and autoimmune diseases. The antibodies c...Wed, 01 Feb 2017 08:44:54 GMTtechnology@musc.edu of GARP antibodies and fusion proteins in cancer, inflammatory and immune conditions, 01 Feb 2017 08:33:21 GMTtechnology@musc.edu class I HDAC inhibitors that are impervious to glucuronidation for the treatment of hematologic malignancies and inflammatory diseases/disorders, 01 Feb 2017 07:34:58 GMTtechnology@musc.edu<![CDATA[Spinal Implant System for Reduction & Internal Implant Stabilization of Human Spondylolisthesis Deformity]]> Hercules spinal implant device and system is to be used for reduction and internal implant stabilization of human vertebral spondylolisthesis deformity. It is a standalone system with unique design that allows an anterior surgical approach to realign and simultaneously stabilize the spinal vertebral segments while protecting and preserve nerve function and not damaging other human body visceral anatomy in order to correct all grades of spondylolisthesis. The proposed solution is to use two implants in the interbody space, allowing greater flexibility to handle high grades of spondylolisthe...Wed, 30 Nov 2016 14:16:50 GMTtechnology@musc.edu CD26hi T-cells for Cancer Therapy, 27 Oct 2016 10:25:02 GMTtechnology@musc.edu of Polychlorinated Biphenyls (PCBs), 28 Sep 2016 12:46:14 GMTtechnology@musc.edu<![CDATA[Cooperative Therapeutic Effect of Immune Checkpoint Blockade & Anti-sMIC]]>, 23 Sep 2016 07:52:31 GMTtechnology@musc.edu Medical Education Videos, 29 Aug 2016 13:02:08 GMTtechnology@musc.edu - A new approach to determine mitochondrial chelatable iron, 26 Jul 2016 14:39:07 GMTtechnology@musc.edu (IP) Health-System Simulation Game for Interprofessional Education Initiatives, 20 Jul 2016 11:56:54 GMTtechnology@musc.edu Rib Hook Fixation Device, 13 Jul 2016 08:23:07 GMTtechnology@musc.edu E61 Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma Proteasome inhibitors (PIs) such as bortezomib/Velcade and carfilzomib/Kyprolis are approved for the treatment of the blood cancer multiple myeloma (MM). While PIs may initially be effective, all patients develop resistance and their disease progresses, marking the incurable nature of this disease. Through an MM drug discovery and high throughput drug-screening (HTS) program at MUSC, researchers have identified a small molecule drug that not only enhances the activity of PIs but also restores sensitivity in MM cells that have acquired resistance. This developmental small molecule d...Wed, 18 May 2016 11:11:54 GMTtechnology@musc.edu Mobile Application for Goniometry at MUSC have developed an interactive, high-quality mobile application for goniometry applicable to physical and occupational therapy. For all upper and lower extremity joint motions, the app provides visual instruction using both labeled pictures and videos. Alternate measurement methods are also included, as are examples of specific precautions, documentation, goal-setting, and functional application. The app is presented in an easy-to-navigate frame with intuitive navigation buttons and is ideal for implementation as a textbook or study aid in physical therapy and occupational the...Fri, 15 Apr 2016 10:59:50 GMTtechnology@musc.edu of Enhanced Adoptive Cellular Therapy without Lymphodepletion, 13 Nov 2015 11:24:59 GMTtechnology@musc.edu Collaborative Software for EEG Data Review and Annotation, 21 Oct 2015 12:41:07 GMTtechnology@musc.edu Wellness Checklist©, 14 Oct 2015 10:08:02 GMTtechnology@musc.edu Telehealth Provider Protocols experts at the Medical University of South Carolina have created protocols as guidelines for treatment by telehealth providers. This telehealth model will require high-definition video conferencing and a suite of diagnostic instruments that provide real-time data to the telehealth provider. These instruments include a digital otoscope and stethoscope. To practice in this telehealth model, providers and telepresenters must meet qualifications established by MUSC. Providers practicing in this model will also be required to participate in a continuing quality assurance program developed ...Thu, 24 Sep 2015 10:07:08 GMTtechnology@musc.edu Electromagnetic Catheter Tracking System for Fluoroscopic and Three-Dimensional Echocardiography, 08 Sep 2015 09:33:03 GMTtechnology@musc.edu Peptide, 25 Aug 2015 11:03:12 GMTtechnology@musc.edu for Generating Superior Anti-tumor T Cell Effector and Memory Cells Inventors have identified a redox-based strategy to generate, expand, and enable redirection of memory T cells. This strategy promotes higher levels of thiols to generate a therapeutic population of T cells for adoptive T cell therapy. These T cells are not only engineered and ex vivo programmed using a unique cell culture conditions that render them with high anti-oxidant property, but also results in low glycolytic and low mitochondrial membrane potential phenotype, which correlates with a superior ability to control established large tumors. This strategy also shows that tumor e...Wed, 22 Jul 2015 10:27:40 GMTtechnology@musc.edu studies toward aza-ellipticine analogs and their potential uses as novel anti-cancer therapeutics is an established anticancer chemotherapeutic, however, its current method of synthesis requires many steps. MUSC researchers have developed a method to obtain ellipticine analogs in one step by utilizing radiation and an acid catalysis. The ellipticine family represents a class of natural products that have been used to develop potential treatments for cancer, HIV, and malarial infection. Recent communications have described rapid access approaches toward quninone4 and aza5 analogs from a common indoline core. Using the MUSC protocol, an alkylated isatin can be derived to form an ...Tue, 02 Jun 2015 09:30:31 GMTtechnology@musc.edu Conductive Nanomaterials Reinforced Cardiac Microtissues Progenitor cells provide strong regenerative ability, but are limited by their immature phenotype and inability to generate functional tissues equivalent to adult cardiomyocytes. This technology provides a novel approach to successfully regenerate functional cardiomyocytes from progenitor cells. The strategy involves providing a physiologically-relevant microenvironment to develop immature stem cells into functional mature cardiomyocytes by incorporating electrically conductive nanomaterials into a scaffold-free, progenitor cell construct that are intrinsically compatible with cath...Tue, 24 Mar 2015 11:39:01 GMTtechnology@musc.edu Histone Deacetylase Inhibitors, 24 Mar 2015 09:01:10 GMTtechnology@musc.edu Software Technologies, 14 Feb 2015 14:38:15 GMTtechnology@musc.edu<![CDATA[Imaging & Surgical Algorithms]]>, 14 Feb 2015 14:17:01 GMTtechnology@musc.edu Medical Devices, 14 Feb 2015 14:05:42 GMTtechnology@musc.edu Diagnostic Technologies, 14 Feb 2015 13:41:12 GMTtechnology@musc.edu Other Therapeutics, 13 Feb 2015 10:18:30 GMTtechnology@musc.edu Neurology Therapeutics Neurology Therapeutics: Therapeutics for Epilepsy and other Neurological Disorders Compounds for Induction of Mitochondrial Biogenesis Nucleosides Analogs for Cardiovascular and Neurodegenerative Diseases, 13 Feb 2015 10:05:24 GMTtechnology@musc.edu Oncology Therapeutics Oncology Therapeutics: Liposomal Delivery of Encapsulated Therapeutics to Treat Pediatric Brain Tumors LSD1 Protein Inhibitors as Epigenetic Modulators Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1) Chaperone-based Integrin Inhibitors for the Treatment of Cancer and Inflammatory Diseases Antibody Therapeutic for EGFR-expressing Cancershttp://musc.technologypublisher...Fri, 13 Feb 2015 10:05:23 GMTtechnology@musc.edu Approach for Combination Cancer Treatments Using Compounds that Block or Interfere with Thromboxane Signaling Pathways, 13 Feb 2015 09:35:05 GMTtechnology@musc.edu Fibrosis Therapeutics Fibrosis Therapeutics Anti-Fibrotic Peptide A Novel Composition for Wound Healing and Tissue Repair Peptide for Treatment and Reversal of Fibrosis Cardiac Repair Therapy Mon, 09 Feb 2015 12:02:12 GMTtechnology@musc.edu Biomimetic Technology to Create Defined Architectures in Hydrogels have developed a biofabrication platform that can be tuned to mimic the native in vivo architecture and geometries vital to the physiological function of tissue. The inventors use a new material for molding intrinsic geometries to an in vitro collagen hydrogel by allowing the adequate transfer of the specific architectural features to a natural scaffold material. The biofabrication platform utilizes state of the art imaging, micromachining, and selective enzymatic activity in order to achieve a new generation of biomaterials for research and clinical applications. The biomaterials ha...Wed, 07 Jan 2015 06:20:40 GMTtechnology@musc.edu Toolkit, 07 Jan 2015 05:30:44 GMTtechnology@musc.edu panel for Predicting Patient Response to Cardiac Resynchronization Therapy, 22 Oct 2014 06:45:06 GMTtechnology@musc.edu Reconstitution and Dilution Compendium The Drug Reconstitution and Dilution Compendium is a PDF compendium of dilution information for over 500 drugs. The guidelines for each medication are presented in a standardized format for ease of viewing. References to the primary reference material are provided. This resource serves as a reference tool for pharmacists and technician in pharmacies and hospitals in which reconstitution and/or dilution of medication is performed. The Reconstitution and Dilution Compendium consists of two PDF documents: A Chemotherapy and Hazardous Medication compendium (145 drugs), and a General Reconstituti...Fri, 10 Oct 2014 12:52:15 GMTtechnology@musc.edu Assessment, 10 Oct 2014 12:42:44 GMTtechnology@musc.edu Assessment, 10 Oct 2014 12:41:36 GMTtechnology@musc.edu Anatomy Video Series The Gross Anatomy Video Series is a series of narrated, demonstrational videos of cadaver dissection meant to supplant instruction during the laboratory component of an anatomy course. The videos can be viewed by students prior to dissection as introductions to the material, or can be used as review tools for content fortification post-dissection. They can also be used by instructors as components of examinations or laboratory practicals. The CDs can also be used by instructors as components of examinations or laboratory practicals. They are available for download as .mp4 video files and can...Fri, 10 Oct 2014 12:25:44 GMTtechnology@musc.edu Screening Assay for Novel Inhibitors of Penicillin Binding Proteins, 25 Sep 2014 10:04:34 GMTtechnology@musc.edu Doctors of Health Obesity Prevention Curriculum, 16 Sep 2014 06:49:01 GMTtechnology@musc.edu of Formalin Fixed Paraffin Embedded Cell Block Preparation of Cytology Specimens at MUSC have created a straightforward method and apparatus to prepare histologic sections from cytologic specimens (cell block). Cell blocks (CB) are a useful adjunct to other cytopreparatory methods, and when successful, yield multiple histologic sections for subsequent special and immunohistochemical (IHC) staining to classify tumors. In addition, CBs provide lesional cells for molecular diagnostics to determine treatment regimens. The apparatus produces CBs quickly, easily, and inexpensively. The specimen processing is uncomplicated and can be readily implemented into any laborat...Thu, 04 Sep 2014 14:06:12 GMTtechnology@musc.edu Screening Assay for Novel Inhibitors of Penicillin Binding Proteins, 20 May 2014 12:43:41 GMTtechnology@musc.edu<![CDATA[Pseudo-Diaphragmatic Expansion Perfusion & Cryopreservation of Intact Viable Tissues]]> at MUSC have developed a rapid and reproducible method for the cryopreservation of a variety of tissues, such that when thawed are comparable to freshly resected tissues. To date, analysis has been completed on lung tissue from patients undergoing lobectomy or transplant and prostate tissue. This method involves the pseudo-diaphragmatic expansion (rapid and thorough perfusion) of pieces of freshly resected tissue utilizing a universal cryoprotectant (PDX-CP) followed by controlled-rate freezing in cryovials. Expansion-perfusion rates, volumes and the cryoprotectant formulation have...Fri, 16 May 2014 05:47:23 GMTtechnology@musc.edu Protein Inhibitors as Cancer Therapeutics Researchers at MUSC have identified several potential inhibitors of lysine-specific demethylase 1 (LSD1) utilizing a virtual screen, and found compounds that fit the LSD1 active site in silico. LSD1 is overexposed in a number of human cancers (neuroblastoma, retinoblastoma, prostate, cancer, lung, and bladder), and has emerged as an important target for the development of specific inhibitors as a new class of antitumor drugs. Researchers have synthesized these molecules and evaluated them as LSD1 inhibitors, and several compounds inhibit the enzyme with Ki values in the mid-to uppe...Tue, 13 May 2014 06:20:04 GMTtechnology@musc.edu Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1), 13 May 2014 06:19:47 GMTtechnology@musc.edu Pulsed Diffusional Kurtosis Imaging Researchers at MUSC have invented a novel double pulsed diffusion magnetic resonance imaging (dMRI) technique, which is referred to as double pulsed diffusional kurtosis imaging (DP-DKI). The technique is essentially an extension of conventional (single-pulsed) DKI to double pulsed field gradient (d-PFG) sequences. This technique leads to a more efficient and practical double pulsed dMRI method that should substantially increase the potential for applications to the clinical assessment of disease by allowing for the quantification of the non-Gaussian diffusion of water within the b...Tue, 08 Apr 2014 11:00:57 GMTtechnology@musc.edu White Matter Fiber Tractography Using Non-Gaussian Diffusion MRI new white matter tractography method based on the dMRI technique of diffusional kurtosis imaging (DKI) has been developed. This method, known as DKI fiber tractography (DKI-FT), substantially improves upon the existing technique because of its ability to resolve intersecting fiber bundles. Moreover, since it is also easily implemented on clinical scanners, DKI-FT is an attractive alternative for clinical applications. Overview: White matter fiber tractography (WMFT) refers to a class of techniques that use data obtained with diffusion magnetic resonance imaging (dMRI) to map axonal fiber bun...Tue, 08 Apr 2014 11:00:56 GMTtechnology@musc.edu Rapamycin Micelle (TRaM) as a Therapeutic and for Solid Organ Transplant TRaMs are a novel therapeutic tool for immunosuppression during solid organ transplantation that encompasses a pH sensitive, self-assembling nanocarrier with encapsulated rapamycin and a targeting moiety for endothelial cells. TRaMs internalize more rapidly than non-targeted RaMs, suppress biomarkers of EC inflammation and reduce MHC expression in vitro. Also, in a co-culture model where T cells are pre-sensitized to mouse cardiac endothelial cells (MCECs), TRaM therapy (100 ng ml-1) significantly reduced IL-8 (data not shown) and IFN- (Figure 1-left) compared to controls. In addi...Fri, 04 Apr 2014 14:00:56 GMTtechnology@musc.edu Mitochondrial Morphology Analysis Software MitoMoby is a high throughput and high content microscopic method for the analysis of mitochondrial morphology (MM) and membrane potential. MitoMoby delineates a procedure for MM analysis using the R platform for data analysis, annotation, and image registration and GE INCell Investigator (specifically, the GE INCell Developer Toolbox package) platform for image analysis. Video Link: Quantitative Analysis of Mitochondrial Morphology Seven measures of morphological analysis are reported in MitoMoby: total mitochondrial object area (comprised of all phenotypes, representative of total mitochon...Wed, 19 Mar 2014 06:34:20 GMTtechnology@musc.edu Endosome Quantifying Software at MUSC have configured a robust, platform-independent algorithm for use of real-time quantification of receptor endosome formation, agonist mobilization, co-localization, areas, and shapes. The algorithm works by segmenting the cells, localizing fluorescently stained nuclei to the segmented outlines, counting the number of small objects within the cells on 2 wavelengths, and then counting the number of co-localizations between the objects. The algorithm contains several improvements over its first iteration including the ability to select a region of interest of cells, faster perf...Mon, 21 Oct 2013 12:52:02 GMTtechnology@musc.edu for Tracking and Invoicing Clinical Research, 19 Apr 2013 08:07:38 GMTtechnology@musc.edu<![CDATA[Services, Pricing & Applications for Research Center (SPARC)]]> A request management system for research services, resources and funding opportunities with enterprise-wide and multi-institutional capacity has been developed. As a web-based system, the software creates a consolidated and paperless process for search, requesting and obtaining pricing for research services, allowing researchers to spend less time locating and requesting services and developing a financial plan for their research. The system offers a personalized User Dashboard and Administrator Portal to manage and track their requests. Additionally, service providers are able to ...Fri, 19 Apr 2013 08:07:34 GMTtechnology@musc.edu Conditions EHR Problem List Data Dictionary, 19 Apr 2013 08:07:32 GMTtechnology@musc.edu SQL Interface, 19 Apr 2013 08:07:21 GMTtechnology@musc.edu Insulin Infusion Calculator with Diagnosis-Specific Modes, 19 Apr 2013 08:06:24 GMTtechnology@musc.edu Based Deception Detection, 19 Apr 2013 08:05:07 GMTtechnology@musc.edu<![CDATA[Electrobiome: Microbial Production of Chemicals & Fuels from Carbon Dioxide]]>, 29 Mar 2013 12:41:48 GMTtechnology@musc.edu Mobile Monitoring of Anesthesia Information Management Systems, 28 Mar 2013 12:19:27 GMTtechnology@musc.edu for Epilepsy and other Neurological Disorders, 27 Mar 2013 12:26:08 GMTtechnology@musc.edu for Detecting Diastolic Heart Failure, 25 Feb 2013 10:17:22 GMTtechnology@musc.edu Left Ventricular Dilation following Myocardial Infarction by Protease and Protease Inhibitor Profiling, 25 Feb 2013 10:17:22 GMTtechnology@musc.edu for Detecting and Monitoring Aortic Aneurysms, 18 Feb 2013 11:24:01 GMTtechnology@musc.edu and Anti-Collagenolytic Dental Materials, 30 Aug 2012 09:51:46 GMTtechnology@musc.edu for Wound Healing and Tissue Repair The inventors have developed a wound-treating material for use in promoting wound healing, decreasing scarring, decreasing inflammation, or promoting formation of healthy tissue architecture post-injury. This JM2 peptide effectively works by blocking hemichannels and lessening ATP release from cells. The JM2 peptide is able to modulate the initial innate immune response to rebuild normal tissue instead of scar tissue. When utilizing the JM2 peptide, there is improved vasculature surrounding an implant capsule with a smaller connective tissue response. This technology has applicatio...Mon, 18 Jun 2012 11:13:55 GMTtechnology@musc.edu Lesion Size Measurements during Cardiac Radiofrequency Catheter Ablation Inventors have developed a radiofrequency ablation (RFA) system, which more accurately estimates lesion size in effort to preserve tissue will be affected during a procedure. The system quantifies blood convection cooling at the cardiac RF catheter ablation site and allows for prediction of lesion size and/or computation of RF energy parameters and characteristics.Overview:With over 400,000 procedures performed worldwide per year (70% in the US), radiofrequency ablation (RFA) is a common, low-invasive procedure used to treat a range of cardiac problems including recurrent atrial fl...Fri, 15 Jun 2012 13:24:08 GMTtechnology@musc.edu Biomarkers for Predicting Recurrence of Atrial Fibrillation Following Cardioversion, 12 Jun 2012 15:11:06 GMTtechnology@musc.edu Left Ventricular Remodeling via Temporal Detection and Measurement of microRNA in Body Fluids invention provides a method of assessing cardiac disease including thoracic aortic aneurysm (TAA) and left ventricular (LV) remodeling by measuring the levels of 5 microRNAs (miRs) in a body fluid such as plasma or serum, or in cardiac and aortic tissue. miRs are small noncoding RNAs that recognize and bind to mRNA and inhibit protein translation or degrade mRNA. This method allows for the assessment of the risk, development, presence, severity, or a combination, of TAA in the subject. In a separate assay, clinicians can assess the presence and/or severity of LV remodeling post ischemia-r...Thu, 08 Mar 2012 06:37:01 GMTtechnology@musc.edu for the Detection and Monitoring of Coronary Artery Disease The inventors have developed a methodology that has been robustly validated (~800 patients) to accurately and reliably measure Ox-LDL, AGE-LDL and other modified LDLs circulating in bound/immune-complex (IC) form. The method involves isolation of IC from blood samples and fractionation of the isolated IC in order to separate modified forms of LDL that can then be quantitated with specific antibodies to Ox-LDL, MDA-LDL and AGE-LDL. The concentrations and relative distribution of modified LDL contained in the IC have been identified as risk factors for the progression of coronary hea...Tue, 19 Apr 2011 07:17:30 GMTtechnology@musc.edu Stable, Non-Nephrotoxic Puromycin Analogs as Oncology and Anti-infective Therapeutics, 27 Mar 2011 11:06:21 GMTtechnology@musc.edu for the Detection and Monitoring of Bladder Cancer, 27 Mar 2011 10:51:25 GMTtechnology@musc.edu