Search Results - Diagnostic

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Biotinylated bioluminescent probe (YuLu) for the detection of luciferase
The global preclinical imaging market is estimated to reach 910 million in the US alone by 2021, including utilizing bioluminescent probes to study biological processes in vitro and in vivo in real time, image cancer cells, monitor gene delivery and adoptively transferred cells and track pathogen clearance, detect apoptosis and research signal tran...
Published: 5/17/2017   |   Inventor(s): Ann-Marie Broome, Yu-Lin Jiang
Keywords(s):  
Category(s): Research Tool, Diagnostic
MUSC Diagnostic Technologies
MUSC Diagnostic Technologies:Methods for Detection of Pancreatic Cancer and other Cancershttp://musc.technologypublisher.com/technology/17462Biomarker panel for Predicting Patient Response to Cardiac Resynchronization Therapyhttp://musc.technologypublisher.com/technology/17411Method of Formalin Fixed Paraffin Embedded Cell Block Preparation of Cyto...
Published: 2/14/2015   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic
Biomarker panel for Predicting Patient Response to Cardiac Resynchronization Therapy
Inventors have identified a specific and unique set of biomarkers that can be developed into a point of care (POC) diagnostic to predict those patients with a high probability of responding to cardiac resynchronization therapy (CRT). Biomarkers have been identified to support the clinical decision of whether CRT will be a meaningful course of trea...
Published: 10/22/2014   |   Inventor(s): Craig Stolen, Timothy Meyer, Milan Seth, Francis Spinale
Keywords(s):  
Category(s): Diagnostic
Method of Formalin Fixed Paraffin Embedded Cell Block Preparation of Cytology Specimens
Inventors at MUSC have created a straightforward method and apparatus to prepare histologic sections from cytologic specimens (cell block). Cell blocks (CB) are a useful adjunct to other cytopreparatory methods, and when successful, yield multiple histologic sections for subsequent special and immunohistochemical (IHC) staining to classify tumors. ...
Published: 9/4/2014   |   Inventor(s): Kathryn Lindsey, Wanda Shotsberger, Patricia Houser, Jack Yang
Keywords(s):  
Category(s): Device, Diagnostic
Biomarkers for Detecting Diastolic Heart Failure
The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies patients with early-stage changes that are indicative of heart failure. These biomarkers can be detected and measured by performing a simple, point-of-care blood test and pro...
Published: 2/25/2013   |   Inventor(s): Francis Spinale, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Predicting Left Ventricular Dilation following Myocardial Infarction by Protease and Protease Inhibitor Profiling
This invention relates to a method of predicting diastolic heart failure in a patient, by identifying, from their body fluid, a profile of MMPs and TIMPs that is associated with the development of left ventricular dilation (LVD). This biomarker panel can identify these patients shortly (1-5 days) after their infarct occurs.Overview:Worldwide, more ...
Published: 2/25/2013   |   Inventor(s): Francis Spinale, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Biomarkers for Detecting and Monitoring Aortic Aneurysms
The inventors have developed a highly specific and sensitive panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies and follows the progression of thoracic aortic aneurysm in patients. These biomarkers can be detected and measured by performing a simple, point...
Published: 2/18/2013   |   Inventor(s): John Ikonomidis, Jeffrey Jones, Rupak Mukherjee, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Plasma Biomarkers for Predicting Recurrence of Atrial Fibrillation Following Cardioversion
The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which can determine patients at risk for recurrent atrial fibrillation (AF). These biomarkers can pre-emptively detect treatment failure for cardioversion activities. These biomarkers can be ...
Published: 6/12/2012   |   Inventor(s): Rupak Mukherjee, Michael Gold, Francis Spinale
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Assessing Left Ventricular Remodeling via Temporal Detection and Measurement of microRNA in Body Fluids
This invention provides a method of assessing cardiac disease including thoracic aortic aneurysm (TAA) and left ventricular (LV) remodeling by measuring the levels of 5 microRNAs (miRs) in a body fluid such as plasma or serum, or in cardiac and aortic tissue. miRs are small noncoding RNAs that recognize and bind to mRNA and inhibit protein translat...
Published: 3/8/2012   |   Inventor(s): Francis Spinale, Michael Zile, Robert Stroud
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Biomarkers for the Detection and Monitoring of Coronary Artery Disease
The inventors have developed a methodology that has been robustly validated (~800 patients) to accurately and reliably measure Ox-LDL, AGE-LDL and other modified LDLs circulating in bound/immune-complex (IC) form. The method involves isolation of IC from blood samples and fractionation of the isolated IC in order to separate modified forms of LDL t...
Published: 4/19/2011   |   Inventor(s): Maria Lopes-Virella, Gabriel Virella
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
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