Search Results - ann-marie broome

5 Results Sort By:
Delivery of chemotherapeutics to brain tumors
Brain cancer is a life-threatening disease with a poor prognosis. This includes Glioblastoma Multiform (GBM), which has a standard treatment of surgical resection, radiation therapy and concurrent chemotherapy with temozolomide (TMZ). The median survival is 14 months because surgeons are unable to completely remove GBM, radiation does not completel...
Published: 5/18/2017   |   Inventor(s): Ann-Marie Broome, Suraj Dixit, Amy-Lee Bredlau
Keywords(s):  
Category(s): Therapeutic
Biotinylated bioluminescent probe (YuLu) for the detection of luciferase
The global preclinical imaging market is estimated to reach 910 million in the US alone by 2021, including utilizing bioluminescent probes to study biological processes in vitro and in vivo in real time, image cancer cells, monitor gene delivery and adoptively transferred cells and track pathogen clearance, detect apoptosis and research signal tran...
Published: 5/17/2017   |   Inventor(s): Ann-Marie Broome, Yu-Lin Jiang
Keywords(s):  
Category(s): Research Tool, Diagnostic
Immunosuppressive Donor Organ Preservation Solution
Inventors have developed a pH sensitive, targeted micelle nanoparticle for the delivery of immunosuppressive agents directly to a donor organ endothelium prior to transplantation as an additive constituent of standard organ preservation solutions. The device will be engineered in such a way as to enable it to penetrate endothelial cells (ECs) to pr...
Published: 1/20/2016   |   Inventor(s): Satish Nadig, Carl Atkinson, Ann-Marie Broome, Suraj Dixit
Keywords(s):  
Category(s): Therapeutic
Microenvironment Modifying Delivery of Alpha-1-Antitrypsin
Inventors are designing a targeted nanocarrier to be used to deliver and protect alpha-1-antitrypsin (A1AT) for the initial therapy of emphysema. The device will be engineered in such a way as to have a protective anti-oxidant coat/shield to prevent the oxidative modification of alpha-1-antitrypsin by the extracellular or intracellular microenviron...
Published: 9/2/2015   |   Inventor(s): Carl Atkinson, Ann-Marie Broome, Satish Nadig
Keywords(s):  
Category(s): Therapeutic
Targeted Rapamycin Micelle (TRaM) as a Therapeutic in Solid Organ Transplant
This technology is a novel therapeutic tool that encompasses a pH sensitive, self-assembling nanocarrier with encapsulated rapamycin, and a targeting moiety for use in targeted immunosuppression during solid organ transplantation. Additionally, this TRaM is conjugated with nearby fluorophores and platelet-derived growth factors to track allograft u...
Published: 4/4/2014   |   Inventor(s): Ann-Marie Broome, Suraj Dixit, Satish Nadig, Carl Atkinson
Keywords(s):  
Category(s): Therapeutic
© 2018. All Rights Reserved. Powered by Inteum