Search Results - diagnostic

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Method of target protein distribution detection in normal and disease-associated protein in thin tissue sections
Technology: Researchers at MUSC have developed a sensitive and reliable matrix- assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) method for in situ reporting extracellular matrix (ECM) sequences localized to tissue, yet without prior knowledge of a specific epitope, increased sequence information compared to most antibody ...
Published: 1/4/2018   |   Inventor(s): Peggi Angel, Richard Drake
Keywords(s):  
Category(s): Diagnostic
Dopamine Gene Variants Predict Response to Aripiprazole in Individuals
Technology: Since medications that can control, regulate, or change the brain dopamine system might be beneficial in treating Alcohol Use Disorder (AUD), MUSC investigators studied the anti-drinking effect of a marketed brain dopamine acting medication, aripiprazole, in individuals with AUD who were genotyped for variants in several brain-functiona...
Published: 10/13/2017   |   Inventor(s): Raymond Anton, Joseph Schacht
Keywords(s):  
Category(s): Diagnostic
The Combination of Two Genetic Variants Can Predict Response to Naltrexone in Individuals with Alcohol Use Disorder (AUD)
Technology: Researchers at MUSC have identified multiple gene variants that are critical for the response to opioid receptor antagonists, including naltrexone for AUD. First, recent work has further validated that carriers of OPRM1 asp40/ DAT10 variable number tandem repeat (VNTR) and asn40/ DAT9 variant carriers do better on naltrexone than other ...
Published: 10/13/2017   |   Inventor(s): Raymond Anton
Keywords(s):  
Category(s): Diagnostic
Biotinylated bioluminescent probe (YuLu) for the detection of luciferase
The global preclinical imaging market is estimated to reach 910 million in the US alone by 2021, including utilizing bioluminescent probes to study biological processes in vitro and in vivo in real time, image cancer cells, monitor gene delivery and adoptively transferred cells and track pathogen clearance, detect apoptosis and research signal tran...
Published: 5/17/2017   |   Inventor(s): Ann-marie Broome, Yu-lin Jiang
Keywords(s):  
Category(s): Research Tool, Diagnostic
MUSC Diagnostic Technologies
MUSC Diagnostic Technologies:Methods for Detection of Pancreatic Cancer and other Cancershttp://musc.technologypublisher.com/technology/17462Biomarker panel for Predicting Patient Response to Cardiac Resynchronization Therapyhttp://musc.technologypublisher.com/technology/17411Method of Formalin Fixed Paraffin Embedded Cell Block Preparation of Cyto...
Published: 2/14/2015   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic
Biomarker panel for Predicting Patient Response to Cardiac Resynchronization Therapy
Inventors have identified a specific and unique set of biomarkers that can be developed into a point of care (POC) diagnostic to predict those patients with a high probability of responding to cardiac resynchronization therapy (CRT). Biomarkers have been identified to support the clinical decision of whether CRT will be a meaningful course of trea...
Published: 10/22/2014   |   Inventor(s): Craig Stolen, Timothy Meyer, Milan Seth, Francis Spinale
Keywords(s):  
Category(s): Diagnostic
Method of Formalin Fixed Paraffin Embedded Cell Block Preparation of Cytology Specimens
Inventors at MUSC have created a straightforward method and apparatus to prepare histologic sections from cytologic specimens (cell block). Cell blocks (CB) are a useful adjunct to other cytopreparatory methods, and when successful, yield multiple histologic sections for subsequent special and immunohistochemical (IHC) staining to classify tumors. ...
Published: 9/4/2014   |   Inventor(s): Kathryn Lindsey, Wanda Shotsberger, Patricia Houser, Jack Yang
Keywords(s):  
Category(s): Device, Diagnostic
Biomarkers for Detecting Diastolic Heart Failure
The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies patients with early-stage changes that are indicative of heart failure. These biomarkers can be detected and measured by performing a simple, point-of-care blood test and pro...
Published: 2/25/2013   |   Inventor(s): Francis Spinale, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Predicting Left Ventricular Dilation following Myocardial Infarction by Protease and Protease Inhibitor Profiling
Technology: This invention relates to a method of predicting diastolic heart failure in a patient, by identifying, from their body fluid, a profile of MMPs and TIMPs that is associated with the development of left ventricular dilation (LVD). This biomarker panel can identify these patients shortly (1-5 days) after their infarct occurs.Overview:Worl...
Published: 2/25/2013   |   Inventor(s): Francis Spinale, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Biomarkers for Detecting and Monitoring Aortic Aneurysms
The inventors have developed a highly specific and sensitive panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies and follows the progression of thoracic aortic aneurysm in patients. These biomarkers can be detected and measured by performing a simple, point...
Published: 2/18/2013   |   Inventor(s): John Ikonomidis, Jeffrey Jones, Rupak Mukherjee, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
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