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N-aroylanthranilic acids and derivatives as inhibitors of bacterial class B transpeptidases
Technology: MUSC inventors identified a new chemical scaffold (N-aroylanthranilic acids and derivatives) as inhibitors of various class B penicillin-binding proteins (PBPs). The novel molecules showed high potency of PBP inhibition. Antimicrobial assays against antibiotic-resistant gonorrhea strain FA19 and H041 showed significant growth inhibition...
Published: 11/9/2020   |   Inventor(s): Jonathan Turner, Christopher Davies, Patrick Woster, Joy Kirkpatrick
Category(s): Therapeutic
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