Search Results - joy+kirkpatrick

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N-aroylanthranilic acids and derivatives as inhibitors of bacterial class B transpeptidases
Technology: MUSC inventors identified a new chemical scaffold (N-aroylanthranilic acids and derivatives) as inhibitors of various class B penicillin-binding proteins (PBPs). The novel molecules showed high potency of PBP inhibition. Antimicrobial assays against antibiotic-resistant gonorrhea strain FA19 and H041 showed significant growth inhibition...
Published: 11/9/2020   |   Inventor(s): Jonathan Turner, Christopher Davies, Patrick Woster, Joy Kirkpatrick
Keywords(s):  
Category(s): Therapeutic
Inhibition of the Histone Demethylase KDM4B Leads to Activation of KDM1A, Attenuates Bacterial-Induced Pro-Inflammatory Cytokine Release and Reduces Osteoclastogenesis
Technology: Researchers at MUSC have discovered a series of novel small molecules that contain potent immunosuppressive activity and can be used as the new treatment for periodontal disease (PD). PD is caused by bacteria infection in dental plaque, which leads to the inflammation response in the area of gums, periodontal ligament or alveolar bone....
Published: 8/13/2019   |   Inventor(s): Patrick Woster, Joy Kirkpatrick
Keywords(s):  
Category(s): Therapeutic
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