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Endodontic surgery tissue retractor (DMND0004574)

Executive Summary Common dental procedures and surgeries require periodontal flap retractation. This includes over 20,000,00 root canals per year where a 20% failure rate is realized in the initial root canal treatment. When engaging in a surgery to repair those that have failed, the surgeon and/or assistant must utilize a tissue retractor device,...

Published: 3/28/2024 | Inventor(s): Joshua Dale

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Category(s): MedTech

Cochlear Implant Quality of Life (CIQOL) Questionnaire

A tool kit used to support audiologists and industry professionals to evaluate the quality of life of patients after cochlear implant surgery. In addition, the tool kit provides a baseline for industry professionals to evaluate potential cochlear implant patients with. This took kit is currently listed as a best practice in the Minimum Speech Battery...

Published: 2/22/2024 | Inventor(s): Theodore McRackan, Craig Velozo, Judy Dubno, Cathy Melvin

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Category(s): Digital Health & Creative Works

RESEARCH TOOL: Biotinylated bioluminescent probe (YuLu) for the detection of luciferase

The global preclinical imaging market is estimated to reach 910 million in the US alone by 2021, including utilizing bioluminescent probes to study biological processes in vitro and in vivo in real time, image cancer cells, monitor gene delivery and adoptively transferred cells and track pathogen clearance, detect apoptosis and research signal transduction....

Published: 5/2/2023 | Inventor(s): Ann-Marie Broome (Deceased), Yu-Lin Jiang

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Category(s): BioPharma

Electrically Conductive Nanomaterials Reinforced Cardiac Microtissues

Technology: Progenitor cells provide strong regenerative ability, but are limited by their immature phenotype and inability to generate functional tissues equivalent to adult cardiomyocytes. This technology provides a novel approach to successfully regenerate functional cardiomyocytes from progenitor cells. The strategy involves providing a physiologically-relevant...

Published: 3/22/2023 | Inventor(s): Donald Menick, Ying Mei, Tan Yu, Dylan Richards, Bozhi Tian

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Category(s): BioPharma

Pseudo-Diaphragmatic Expansion Perfusion & Cryopreservation of Intact Viable Tissues

Researchers at MUSC have developed a rapid and reproducible method for the cryopreservation of a variety of tissues, such that when thawed are comparable to freshly resected tissues. To date, analysis has been completed on lung tissue from patients undergoing lobectomy or transplant and prostate tissue. This method involves the pseudo-diaphragmatic...

Published: 3/23/2023 | Inventor(s): John Baatz, Demetri d. Spyropoulos

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Category(s): BioPharma

Kinetic targeting of intravascular triggered drug delivery system

Device for Vascular Filtration of Excess Chemotherapeutic Containing Thermally Sensitive Liposomes via Kinetic TargetingTechnology: Researchers at MUSC have created a device and method that can remove excess chemotherapeutic containing Intravascular Triggered Drug Delivery Systems (IVDDSs) that are utilized in localized drug treatment, thus greatly...

Published: 2/7/2023 | Inventor(s): Dieter Haemmerich, Anjan Motamarry

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Category(s): MedTech

Biopsy Clip Metal Detector to Aid Breast Surgery

This metal detector localizes biopsy clips (e.g. titanium) placed at the site of breast tissue biopsies. The device is a handheld metal detector that can be inserted into a surgical incision to help locate small markers without an invasive procedure to insert a localizing wire, radioactive seed, or other localization technologies. The device is able...

Published: 2/7/2023 | Inventor(s): Nancy DeMore, Delphine Dean, Scott Slaney, Joseph Wilson III, Cody Jordan, Melissa McCullough

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Category(s): MedTech

G9a inhibition decreases stress-induced escalation of alcohol drinking

Technology: Inventors at MUSC have identified that NAc (nucleus accumbens) G9a is required for stress-regulated drinking in both ethanol-dependent and non-dependent animals. Importantly they discovered that treating mice with UNC0642 (an inhibitor of G9a) in a stressinduced ethanol drinking assay (Figure. 1A) showed significant reduction in ethanol...

Published: 8/23/2023 | Inventor(s): Ethan Anderson, Christopher Cowan

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Category(s): BioPharma

CaMKK-β as a target for prevention of noise- and aminoglycoside-induced hearing loss

Compositions and Methods for Attenuation of Hearing Loss Technology: Researchers at MUSC have developed a biopharmaceutical therapy that reduces the expression of specific proteins associated with both noise and chemically induced hearing loss. The invention provides a gene therapy and therapeutic target for prevention of acquired hearing loss. Previous...

Published: 3/23/2023 | Inventor(s): Su-Hua Sha

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Category(s): BioPharma

Monobody R15 targets the nucleotide free state of RAS to block oncogenic signaling and transformation

Technology: Researchers at MUSC and NYU Langone Medical Center have identified a synthetic protein (R15) that selectively binds to the nucleotide-free state of the RAS proto-oncogene (apoRAS) and is the first experimental tool to selectively inhibit the signaling and oncogenic activity of selected oncogenic RAS mutants (Figure 1). The synthetic protein...

Published: 3/23/2023 | Inventor(s): John O'Bryan, Shohei Koide, Akiko Koide

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Category(s): BioPharma

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