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Biopsy Clip Metal Detector to Aid Breast Surgery
This metal detector localizes biopsy clips (e.g. titanium) placed at the site of breast tissue biopsies. The device is a handheld metal detector that can be inserted into a surgical incision to help locate small markers without an invasive procedure to insert a localizing wire or radioactive seed. The device uses a two-step detection system which i...
Published: 1/12/2018   |   Inventor(s): Nancy DeMore, Delphine Dean, Scott Stanley, Joseph Wilson III, Cody Jordan, Melissa McCullough
Keywords(s):  
Category(s): Device
TOBI: Telemedicine Optimized Burn Intervention
MUSC experts in pediatric burn care, health communication, nursing, public health, biostatistics, information technology, and clinical psychology have developed a mobile application (TOBI) that allows for tertiary clinical burn care in the home by connecting patients and families with expert burn nurses and physicians. The app enables burn physicia...
Published: 1/4/2018   |   Inventor(s): Aaron Lesher, Sachin Patel, Ryan Howard, Frank A Treiber
Keywords(s):  
Category(s): Software
Method of target protein distribution detection in normal and disease-associated protein in thin tissue sections
Technology: Researchers at MUSC have developed a sensitive and reliable matrix- assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) method for in situ reporting extracellular matrix (ECM) sequences localized to tissue, yet without prior knowledge of a specific epitope, increased sequence information compared to most antibody ...
Published: 1/4/2018   |   Inventor(s): Peggi Angel, Richard Drake
Keywords(s):  
Category(s): Therapeutic
Smart Wound Healing Matrix
MUSC researchers have invented a multi-layered system designed to reduce healing time of difficult to heal wounds such as enterocutaneous and enteroatmospheric fistulas, pressure ulcers, diabetic wounds, among others. This multilayer and multifaceted smart wound dressing (SWOD) device addresses many of the limitations of current wound healing strat...
Published: 11/27/2017   |   Inventor(s): Michael Yost, Stephen Fann, J. Matthew Rhett, Veronica Rodriguez-Rivera, Heather Bainbridge, Sarah Dennis
Keywords(s):  
Category(s): Device
Chamber for Cyroprotectant Tissues Perfusion and Bioengineered Tissue Scaffolds
The chamber is for use in the rapid stabilization of cell viability and tissue architecture post tissue freezing and thawing. These chambers were created to address the inefficiencies of the syringe-only approach surrounding the proprietary cryoprotectant and perfusion protocol (CPP). There are currently three perfusion chamber systems: 1) a &lsqu...
Published: 11/6/2017   |   Inventor(s): John Baatz, Demetri D. Spyropoulos
Keywords(s):  
Category(s): Therapeutic
Dopamine Gene Variants Predict Response to Aripiprazole in Individuals
Technology: Since medications that can control, regulate, or change the brain dopamine system might be beneficial in treating Alcohol Use Disorder (AUD), MUSC investigators studied the anti-drinking effect of a marketed brain dopamine acting medication, aripiprazole, in individuals with AUD who were genotyped for variants in several brain-functiona...
Published: 10/13/2017   |   Inventor(s): Raymond Anton, Joseph Schacht
Keywords(s):  
Category(s): Therapeutic
The Combination of Two Genetic Variants Can Predict Response to Naltrexone in Individuals with Alcohol Use Disorder (AUD)
Technology: Researchers at MUSC have identified multiple gene variants that are critical for the response to opioid receptor antagonists, including naltrexone for AUD. First, recent work has further validated that carriers of OPRM1 asp40/ DAT10 variable number tandem repeat (VNTR) and asn40/ DAT9 variant carriers do better on naltrexone than other ...
Published: 10/13/2017   |   Inventor(s): Raymond Anton
Keywords(s):  
Category(s): Therapeutic
Linear Array of Multi-substrate Cell Migration Assay (LAMA)
The invention is a cell migration chamber that allows for multiple substrates to be used in a single assay. The system uses parallel tracks of different substrates and a gap migration technique. This system and method allows for cell adhesion, migration and differentiation on up to 20 different test conditions simultaneously using only minute amoun...
Published: 10/9/2017   |   Inventor(s): Ricardo Moreno
Keywords(s):  
Category(s): Device
Total Body Irradiation Using Pre-Existing Dose Dynamic Fields
Technology: TA library of pre-commissioned dose dynamic fields offers a simple method for delivery of total body irradiation (TBI) given in preparation for transplant. This simple technique is available for any VMAT-capable machine, regardless of the treatment room size or span of the MLCs, yet does not require complex planning or patient-specific ...
Published: 10/9/2017   |   Inventor(s): Nicholas Koch
Keywords(s):  
Category(s): Therapeutic
Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1- Sickle Cell Disease
Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1) for Sickle Cell Disease Technology: Researchers at MUSC have used a ligand-based approach to design and synthesize a series of cyclic peptides that are effective inhibitors of LSD1, and have greater stability to proteolytic degradation than their linear homologues. For example, cycli...
Published: 9/13/2017   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
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