Search Results - shikhar mehrotra

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CD38 mediated metabolic axis in anti-tumor T cell immunotherapy
Tumor-induced immune suppression constitutes an important barrier for effective anti-tumor immunity and immunotherapy in cancer. MUSC inventors’ preliminary data suggests that targeting CD38 expression on anti-tumor T cells result in decreased NAD+ levels, which has been shown to result in increased longevity and epigenetically regulating th...
Published: 5/12/2017   |   Inventor(s): Shikhar Mehrotra, Shilpak Chatterjee
Keywords(s):  
Category(s): Therapeutic
Processes for Generating Superior Anti-tumor T Cell Effector and Memory Cells
Inventors have identified a redox-based strategy to generate, expand, and enable redirection of memory T cells. This strategy promotes higher levels of thiols to generate a therapeutic population of T cells for adoptive T cell therapy. These T cells are not only engineered and ex vivo programmed using a unique cell culture conditions that render th...
Published: 7/22/2015   |   Inventor(s): Shikhar Mehrotra, Michael Nishimura, Pravin Kesarwani, Shilpak Chatterjee
Keywords(s):  
Category(s): Therapeutic
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