Search Results - suraj dixit

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Delivery of chemotherapeutics to brain tumors
Brain cancer is a life-threatening disease with a poor prognosis. This includes Glioblastoma Multiform (GBM), which has a standard treatment of surgical resection, radiation therapy and concurrent chemotherapy with temozolomide (TMZ). The median survival is 14 months because surgeons are unable to completely remove GBM, radiation does not completel...
Published: 5/18/2017   |   Inventor(s): Ann-Marie Broome, Suraj Dixit, Amy-Lee Bredlau
Keywords(s):  
Category(s): Therapeutic
Immunosuppressive Donor Organ Preservation Solution
Inventors have developed a pH sensitive, targeted micelle nanoparticle for the delivery of immunosuppressive agents directly to a donor organ endothelium prior to transplantation as an additive constituent of standard organ preservation solutions. The device will be engineered in such a way as to enable it to penetrate endothelial cells (ECs) to pr...
Published: 1/20/2016   |   Inventor(s): Satish Nadig, Carl Atkinson, Ann-Marie Broome, Suraj Dixit
Keywords(s):  
Category(s): Therapeutic
Targeted Rapamycin Micelle (TRaM) as a Therapeutic in Solid Organ Transplant
This technology is a novel therapeutic tool that encompasses a pH sensitive, self-assembling nanocarrier with encapsulated rapamycin, and a targeting moiety for use in targeted immunosuppression during solid organ transplantation. Additionally, this TRaM is conjugated with nearby fluorophores and platelet-derived growth factors to track allograft u...
Published: 4/4/2014   |   Inventor(s): Ann-Marie Broome, Suraj Dixit, Satish Nadig, Carl Atkinson
Keywords(s):  
Category(s): Therapeutic
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