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Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)

Technology: Researchers at MUSC have discovered HDAC1 is present in the adult cardiac myocyte mitochondria. A series of HDAC1 inhibitors that target mitochondria have been made (MitoDACs). One of the analogs, LL-66, localizes to the mitochondria and is absent from the nucleus in isolated adult rat cardiac myocytes. Inhibiting activity of HDAC1...

Published: 3/22/2023 | Inventor(s): Donald Menick, Chung-Jen (James) Chou, Daniel Herr, Xiaoyang (李晓杨) Li

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Category(s): BioPharma