Bacteriostatic and Anti-Collagenolytic Dental Materials


Through the incorporation of polyacrylic acid modified CUQ nanoparticles, the present technology provides an entire line of dental products including sealants, structural components, and a variety of RBCs that have antimicrobial properties built into the product, reducing the recurrent bacterial driven decay.


Overview: Restorative dentistry due to tooth decay continues to grow around the world. The use of resin based composites (RBCs) is preferred because of the aesthetic quality of RBCs in matching background tooth color. However, RBCs continue to have a high rate of long term decay to the underlying tooth structure because of imperfect sealing and microleakage, allowing bacteria to infiltrate the RBC and area between the RBC and the tooth. Replacement of failed dental restorations alone is a $5 billion per year market.


Advantages: Restorative dental procedures with less after procedure bacterial infection


Applications: All dental uses of resin based composites


Keywords: Dental, resin based composite, dental caries


Publications: Renné, Walter G., et al. "Antibacterial properties of copper iodide-doped glass ionomer-based materials and effect of copper iodide nanoparticles on collagen degradation." Clinical Oral Investigations (2016): 1-11.


Sabatini, Camila, et al. "Incorporation of bactericidal poly-acrylic acid modified copper iodide particles into adhesive resins." Journal of dentistry43.5 (2015): 546-555.


Inventors: W.G. Renne, M.G. Schmidt, A.S. Mennito

Patent Status: US Patent 9,034,354

MUSC-FRD Technology ID: P1224


License Status: This technology is licensed to MUSC startup, CuRE Innovations. Please contact the FRD for more information or to be put in touch with CuRE Innovations.

Patent Information:
For Information, Contact:
Troy Huth
Assoc Director
MUSC Foundation for Research Development
Walter Renne
Michael Schmidt
Anthony Mennito
Jompobe Vuthiganon
George Chumanov
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