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Novel class I HDAC inhibitors that are impervious to glucuronidation for the treatment of hematologic malignancies and inflammatory diseases/disorders
MUSC researchers have developed a series of potent and selective class I histone deacetylase (HDAC) inhibitors. Currently, approved HDAC inhibitors are generated using hydroxamic acid or a benzylic amine motif and suffer from toxicity, off-target effects, and metabolic inactivation. Furthermore, the first generation HDAC inhibitors have been shown...
Published: 2/1/2017   |   Inventor(s): Chung-Jen (James) Chou, Jesse Mcclure, Cheng Zhang, Elizabeth Inks
Category(s): Therapeutic
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