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Pharmaceuticaly Modified T cells for Adoptive Cell Therapy Against Cancer

Technology: Inventors from MUSC have identified that inhibiting PI3Kδ and β-catenin pathway enhances anti-tumor functions of Th17 cells in adoptive T cell therapy (ACT). The inventors have discovered that expansion of Th17 cells in vitro with CAL-101 and indomethacin inhibitors generated T cells with augmented memory phenotype (enhanced CD62L...

Published: 7/10/2017 | Inventor(s): Chrystal Paulos, Kinga Majchrzak, Jacob Bowers

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Category(s): Therapeutic