Search Results - chrystal paulos

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Pharmaceuticaly Modified T cells for Adoptive Cell Therapy Against Cancer

Inventors have found that treatment of tumor-reactive human T cells with drugs that co-modulate β-catenin and PI3Kδ enhances their antitumor capacity, especially their ability to exert a long-term immune response against cancer. Th17 cells inhibited of both pathways expressed less RORγt, which, in turn, reduced their ability to sec...

Published: 7/10/2017 | Inventor(s): Chrystal Paulos, Kinga Majchrzak, Jacob Bowers

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Category(s): Therapeutic

Targeting CD26hi T-cells for Cancer Therapy

Inventors at MUSC have identified a unique human CD4+ T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies. CD26high T cells simultaneously secrete elevated IL-17A, IFN- and IL-...

Published: 10/27/2016 | Inventor(s): Michelle Nelson, Stefanie Bailey, Chrystal Paulos

Keywords(s):

Category(s): Therapeutic