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Application of GARP antibodies and fusion proteins in cancer, inflammatory and immune conditions
Researchers at MUSC have demonstrated that GARP is a novel oncogene due to its cancer-intrinsic roles in promoting invasion and metastasis, as well as its cancer-extrinsic roles in inducing immune tolerance. Administration of a GARP-specific mAb limited metastasis and resulted in an effective cancer therapy in a mouse model of breast cancer (Fig 1)...
Published: 2/1/2017   |   Inventor(s): Zihai Li
Keywords(s): cancer, immune, therapeutic
Category(s): Therapeutic
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