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Biomarkers for Detecting Diastolic Heart Failure

The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies patients with early-stage changes that are indicative of heart failure. These biomarkers can be detected and measured by performing a simple, point-of-care blood test and provide...

Published: 2/25/2013 | Inventor(s): Francis Spinale, Robert Stroud, Michael Zile

Keywords(s): cardiovascular, diagnostic

Category(s): Diagnostic

Predicting Left Ventricular Dilation following Myocardial Infarction by Protease and Protease Inhibitor Profiling

Technology: This invention relates to a method of predicting diastolic heart failure in a patient, by identifying, from their body fluid, a profile of MMPs and TIMPs that is associated with the development of left ventricular dilation (LVD). This biomarker panel can identify these patients shortly (1-5 days) after their infarct occurs.Overview:Worldwide,...

Published: 2/25/2013 | Inventor(s): Francis Spinale, Robert Stroud, Michael Zile

Keywords(s): cardiovascular, diagnostic

Category(s): Diagnostic

Assessing Left Ventricular Remodeling via Temporal Detection and Measurement of microRNA in Body Fluids

This invention provides a method of assessing cardiac disease including thoracic aortic aneurysm (TAA) and left ventricular (LV) remodeling by measuring the levels of 5 microRNAs (miRs) in a body fluid such as plasma or serum, or in cardiac and aortic tissue. miRs are small noncoding RNAs that recognize and bind to mRNA and inhibit protein translation...

Published: 3/8/2012 | Inventor(s): Francis Spinale, Michael Zile, Robert Stroud

Keywords(s): cardiovascular, diagnostic

Category(s): Diagnostic