Search Results - michael zile

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Biomarkers for Detecting Diastolic Heart Failure

The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies patients with early-stage changes that are indicative of heart failure. These biomarkers can be detected and measured by performing a simple, point-of-care blood test and pro...

Published: 2/25/2013 | Inventor(s): Francis Spinale, Robert Stroud, Michael Zile

Keywords(s): cardiovascular, diagnostic

Category(s): Diagnostic

Predicting Left Ventricular Dilation following Myocardial Infarction by Protease and Protease Inhibitor Profiling

Technology: This invention relates to a method of predicting diastolic heart failure in a patient, by identifying, from their body fluid, a profile of MMPs and TIMPs that is associated with the development of left ventricular dilation (LVD). This biomarker panel can identify these patients shortly (1-5 days) after their infarct occurs.Overview:Worl...

Published: 2/25/2013 | Inventor(s): Francis Spinale, Robert Stroud, Michael Zile

Keywords(s): cardiovascular, diagnostic

Category(s): Diagnostic

Biomarkers for Detecting and Monitoring Aortic Aneurysms

The inventors have developed a highly specific and sensitive panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies and follows the progression of thoracic aortic aneurysm in patients. These biomarkers can be detected and measured by performing a simple, point...

Published: 2/18/2013 | Inventor(s): John Ikonomidis, Jeffrey Jones, Rupak Mukherjee, Robert Stroud, Michael Zile

Keywords(s): cardiovascular, diagnostic

Category(s): Diagnostic

Assessing Left Ventricular Remodeling via Temporal Detection and Measurement of microRNA in Body Fluids

This invention provides a method of assessing cardiac disease including thoracic aortic aneurysm (TAA) and left ventricular (LV) remodeling by measuring the levels of 5 microRNAs (miRs) in a body fluid such as plasma or serum, or in cardiac and aortic tissue. miRs are small noncoding RNAs that recognize and bind to mRNA and inhibit protein translat...

Published: 3/8/2012 | Inventor(s): Francis Spinale, Michael Zile, Robert Stroud

Keywords(s): cardiovascular, diagnostic

Category(s): Diagnostic