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Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCR)

Pathologies associated with Luteinizing hormone-releasing hormone LHRH include a number of cancers, prostate hyperplasia, endometriosis, uterine fibroids and polycystic ovary syndrome. Analogues for LHRH have been developed to treat gynecological disorders and cancers, including leuprolide and triptorelin. However, agonists of LHRH lead to total pharmacologic...

Published: 9/17/2018 | Inventor(s): Klaus Paulini, Matthias Gerlach, Eckhard Guenther, Emmanuel Polymeropoulos, Silke Baasner, Peter Schmidt, Ronald Kuhne, Arvid Soderhall

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Category(s): Therapeutic