Search Results - shilpak chatterjee

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CD38 mediated metabolic axis in anti-tumor T cell immunotherapy
Technology: MUSC researchers have identified T cells with reduced surface expression of NADase CD38 exhibited intrinsically higher NAD+ levels, enhanced oxidative phosphorylation, higher glutaminolysis and altered mitochondrial dynamics that vastly improved tumor control. Inventors identified combining the culture conditions of Th17ILβ+TGF&bet...
Published: 5/12/2017   |   Inventor(s): Shikhar Mehrotra, Shilpak Chatterjee
Keywords(s):  
Category(s): Therapeutic
Processes for Generating Superior Anti-tumor T Cell Effector and Memory Cells
Technology: Inventors have identified a redox-based strategy to generate, expand, and enable redirection of memory T cells. This strategy promotes higher levels of thiols to generate a therapeutic population of T cells for adoptive T cell therapy. These T cells are not only engineered and ex vivo programmed using a unique cell culture conditions th...
Published: 7/22/2015   |   Inventor(s): Shikhar Mehrotra, Michael Nishimura, Pravin Kesarwani, Shilpak Chatterjee
Keywords(s):  
Category(s): Therapeutic
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