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Delivery of CR2-fH complement inhibitors using gene therapy as novel treatment for age-related macular degeneration (AMD)

Technology: A group of MUSC researchers have developed a novel gene therapy technique to treat age-related macular degeneration (AMD) pathogenesis by introducing a novel complement inhibitory fusion protein (CR2-fH) via an adeno-associated virus (AAV). Data gathered showed that after subretinal delivery of AAV-VMD2-CR2-fH in C57BL/6J mice, the secretion...

Published: 6/21/2019 | Inventor(s): Monica Vetter, Alejandra Bosco, Baerbel Rohrer, William Hauswirth

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Category(s): Therapeutic