Biomarkers for Detecting Diastolic Heart Failure

Description:

The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies patients with early-stage changes that are indicative of heart failure. These biomarkers can be detected and measured by performing a simple, point-of-care blood test and provide earlier detection than the current diagnostic tests.

 

Overview:

One million patients per year are diagnosed with heart failure upon presenting to the emergency room with symptoms such as shortness of breath. Troponin, NT-proBNP, and echocardiogram (ECG) are the current diagnostic tools for heart failure. None of the current tools are able to detect the disease in its earliest stages. There is a growing need for a preventative approach to identify patients earlier who are at risk for developing heart failure. The damage incurred by this disease is currently irreversible, so early detection and preventative care is of utmost importance. Early intervention will improve patient outcomes and results in significantly reduced costs.

 

Advantages:

Earlier identification of patients at risk for diastolic heart failure

 

Key Words: Hypertrophic heart failure, congestive heart failure - CHF, heart failure with reduced ejection fraction – HFrEF, remodeling, hypertension, obesity, diabetes, diagnostic

 

Inventors:                                F.G. Spinale, M.R. Zile, R.E. Stroud                

Patent Status:                         US Utility Application 12/299,999, Filed 4/24/2007 (Notice of Allowance)

MUSC-FRD Technology ID:    P0619

Patent Information:
Category(s):
Diagnostic
For Information, Contact:
Marketing / Licensing Officer
Marketing/Licensing Officer
MUSC Foundation for Research Development
technology@musc.edu
Inventors:
Francis Spinale
Robert Stroud
Michael Zile
Keywords:
cardiovascular
diagnostic
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