Coronary heart disease is the leading cause of death in the United States. While one American death in every five annually is caused by coronary heart disease, treatment options remain limited. Once injury to the heart occurs, the cardiac healing process is dominated by scar tissue formation. This leads to a diminished function of the damaged heart as a blood pump and increased risk of cardiac arrhythmia and sudden death. The exciting prospect of this licensing opportunity is that it is a potential therapy that would encourage the regeneration of heart muscle rather than scar tissue following a heart attack. A successful and safe approach to regenerative repair of the heart would truly revolutionize the standard of care for patients suffering from coronary heart disease.
Differentiation, proliferation, and repopulation of cardiac scars with new functional myocytes
Therapeutic for cardiac regeneration, as well as other diseases where scar formation is a problem
Keywords: Cardiac, stem cell, periostin, scar formation
Inventors: R. Norris, R. Gourdie, M. O'Quinn, R. Markwald
Patent Status: US Utility Application 12/631,655, filed 12/04/2009
MUSC-FRD Technology ID: P0905