Search Results - christopher+lindsey

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5HT1F receptor ligands that induce mitochondrial biogenesis
Technology: MUSC investigators have synthesized new chemical entity analogues for 5HT1F receptors. These structurally unique novel chemical entities act as agonists to the serotonin class-1F (5HT1F) receptors and were found to be potent inducers of mitochondrial biogenesis (MB) in vitro. Also, several of the compounds were tested and found to induce...
Published: 6/27/2018   |   Inventor(s): Christopher Lindsey, Craig Beeson, Rick Schnellmann, Yuri Peterson
Keywords(s):  
Category(s): Therapeutic
Mitoferrofluor - A new approach to determine mitochondrial chelatable iron
Inventors have created a fluorescent marker, mitoferrofluor (MFF) for measuring mitochondrial chelatable iron in living cells and tissues. It is an improvement on existing markers, as it covalently bonds to the mitochondria once it has entered, thus it will remain there through any subsequent reactions. Iron is an essential nutrient. Incorporation...
Published: 7/26/2016   |   Inventor(s): John Lemasters, Andaleb Kholmukhamedov, Christopher Lindsey, Craig Beeson
Keywords(s):  
Category(s): Other
Ellipticine Analogs as Anti-Cancer Therapeutics
Technology: Ellipticine is an established anticancer chemotherapeutic, however, its current method of synthesis requires many steps and has an unfavorable toxicity profile. MUSC researchers have developed a method to obtain ellipticine analogs in one step by utilizing radiation and acid catalysis. These analogs have unique characteristics that may improve...
Published: 6/2/2015   |   Inventor(s): Christopher Lindsey, Craig Beeson
Keywords(s):  
Category(s): Therapeutic
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