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Monobody R15 targets the nucleotide free state of RAS to block oncogenic signaling and transformation

Technology: Researchers at MUSC and NYU Langone Medical Center have identified a synthetic protein (R15) that selectively binds to the nucleotide-free state of the RAS proto-oncogene (apoRAS) and is the first experimental tool to selectively inhibit the signaling and oncogenic activity of selected oncogenic RAS mutants (Figure 1). The synthetic protein...

Published: 4/29/2024 | Inventor(s): John O'Bryan, Shohei Koide, Akiko Koide

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Category(s): BioPharma