Description:
Technology: Inventors from MUSC have identified a class of brominated alkaloid compounds, including aleutianamine, which has potent bioactivity across multiple cancer cell lines in vitro. Extraction and purification of specimens of Latrunculia austini, led to isolation of a potential target mass m/z 398 that resulted from MS/MS molecular ion networking-MoIN analysis (vide supra) as a green-yellow solid with the molecular formula of C18H13BrN3OS generated by high-resolution mass spectrometry analysis (Figure 1). Aleutianamine, with its unique ring system, showed anti-cancer selectivity in a differential cytotoxicity zone assay. Aleutianimine selectively killed pancreatic cancer PANC-1 cell line and murine colon cancer 38, human breast cancer cell line MCF-7, human prostate cancer LNCaP. The IC50 value for aleutianamine tested against human HCT-116 colon cancer cells was 1 μM and against PANC-1 pancreatic cancer cells were 25 nM, indicating significant potency and selectivity towards pancreatic cancer. Overall, this new compound class provides a new opportunity to treat cancers, including difficult to treat pancreatic cancer.
![](data:image/png;base64,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)
![](data:image/png;base64,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)
Overview: Pancreatic cancer is one of the deadliest cancers with a 5-year survival rate of less than 8%. The only curative therapy is surgery for which only 15−20% of patients are eligible and of those about 20% are long-term survivors. Hence there is an urgent need for novel therapeutic approaches for pancreatic cancer treatment. Currently, Gemcitabine and Abraxane among other chemotherapeutic drugs are used against pancreatic cancer treatment with limited success. Although standard chemotherapeutic treatments for pancreatic cancer add months to a patient’s overall survival time, there is little improvement in survival rates. Using computational and mass spectroscopic methods, MUSC inventors have identified a novel aleutianamine compound with effective cell killing against PANC-1 cancer cells. Aleutianamine showed significantly higher cytotoxicity than discorhabdin A (precursor in the biosynthesis of Aleutianamine) toward cancer cell lines and demonstrated selective inhibition to pancreatic cancer cell lines. Thus, developing an aleutianamine based compound could be an effective strategy for treating pancreatic cancer.
Applications: A novel therapeutic approach that could improve chemotherapy for treating pancreatic cancer.
Advantages: A new alkaloid isolated from Latrunculia austini could be a novel therapeutic compound against pancreatic cancer.
Key Words: Pancreatic cancer, aleutianamine, alkaloids, Abraxane, Gemcitabine, PANC-1.
Publication: Zou Y, Wang X, Sims J, Wang B, Pandey P, Welsh C, Stone RS, Avery MA, Doerksen RJ, Ferreira D, Anklin C, Valeriote FA, Kelly M, Hamann MT. Computationally-Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean. J Am Chem Soc. 2019 Feb 13.
Inventors: Fred Valeriote, Mark T. Hamann
Patent Status: Provisional filed on 12.26.2018.
MUSC-FRD Technology ID: P1938