Search Results - carl atkinson

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Immunosuppressive Donor Organ Preservation Solution
Inventors have developed a pH sensitive, targeted micelle nanoparticle for the delivery of immunosuppressive agents directly to a donor organ endothelium prior to transplantation as an additive constituent of standard organ preservation solutions. The device will be engineered in such a way as to enable it to penetrate endothelial cells (ECs) to pr...
Published: 1/20/2016   |   Inventor(s): Satish Nadig, Carl Atkinson, Ann-Marie Broome, Suraj Dixit
Keywords(s):  
Category(s): Therapeutic
Microenvironment Modifying Delivery of Alpha-1-Antitrypsin
Inventors are designing a targeted nanocarrier to be used to deliver and protect alpha-1-antitrypsin (A1AT) for the initial therapy of emphysema. The device will be engineered in such a way as to have a protective anti-oxidant coat/shield to prevent the oxidative modification of alpha-1-antitrypsin by the extracellular or intracellular microenviron...
Published: 9/2/2015   |   Inventor(s): Carl Atkinson, Ann-Marie Broome, Satish Nadig
Keywords(s):  
Category(s): Therapeutic
Targeted Rapamycin Micelle (TRaM) as a Therapeutic in Solid Organ Transplant
This technology is a novel therapeutic tool that encompasses a pH sensitive, self-assembling nanocarrier with encapsulated rapamycin, and a targeting moiety for use in targeted immunosuppression during solid organ transplantation. Additionally, this TRaM is conjugated with nearby fluorophores and platelet-derived growth factors to track allograft u...
Published: 4/4/2014   |   Inventor(s): Ann-Marie Broome, Suraj Dixit, Satish Nadig, Carl Atkinson
Keywords(s):  
Category(s): Therapeutic
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