Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis

Description:

Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic Diseases

 

Technology:  While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized hydrogel microarray technology to identify peptides with high affinity to endothelial cell integrin. Leveraging the recent advances in bioinformatics, a library of RGD peptides derived from various vascular endothelium extracellular matrix proteins was constructed. The newly established peptide functionalized hydrogel microarray was then used to screen the RGD peptide library for the high affinity ligands to endothelial cell integrin. This enabled the identification of a RGD peptide with dramatically enhanced ability to promote endothelial cell adhesion, spreading, and proliferation in comparison with the currently used RGDS/RGDS peptide.

 

 

Overview: This bi-functional RGD peptide helps identify ligands and improve functions of endothelial cells, allowing for the development of biomaterials to treat ischemic diseases. According to the Center for Disease Control and Prevention, over 795,000 people in the United States suffer a stroke each year. Of these cases, 87 percent are caused by ischemia – the restriction of blood flow to tissue. Ischemia causes a reduction in oxygen and energy as well as a build-up of waste products for tissues and organs. In severe cases, it can cause organ failure and lead to diseases such as ischemic heart disease or stroke. Recent research, however, suggests therapeutic angiogenesis holds remarkable promise to treat ischemic diseases and for developing viable tissue engineering strategies. To this end, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide-functionalized hydrogel microarray to identify a bi-functional RGD peptide that promotes therapeutic angiogenesis. This discovery allows for the development of multi-functional biomaterials for treating ischemic diseases and the fabrication of pre-vascularized tissue engineering constructs.

 

Applications:  Biomaterials; tissue engineering; ischemic diseases

 

Advantages:

-       Allows for the development of pro-angiogenic biomaterials, assisting in the treatment of ischemic diseases

-       Demonstrates significantly improved properties to promote endothelial cell functions over currently used peptides

 

Key Words: ischemia, heart attack, stroke, angiogenesis, tissue engineering

 

Inventors:  James Chou, Ying Mei and Jia Jia

Patent Status: U.S. Patent Application 15/726,766 filed October 6th, 2017

MUSC-FRD Technology ID:  P1705

Licensing Status: Available for licensing

 

Patent Information:
Category(s):
Therapeutic
For Information, Contact:
Troy Huth
Sr Licensing Manager
MUSC Foundation for Research Development
huth@musc.edu
Inventors:
Chung-Jen (James) Chou
Ying Mei
Jia Jia
Keywords:
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