Search Results - chung-jen (james) chou

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Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis
Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic DiseasesTechnology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized h...
Published: 9/6/2018   |   Inventor(s): Chung-Jen (James) Chou, Ying Mei, Jia Jia
Keywords(s):  
Category(s): Therapeutic
Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)
Technology: Researchers at MUSC have discovered HDAC1 is present in the adult cardiac myocyte mitochondria. A series of HDAC1 inhibitors that target mitochondria have been made (MitoDACs). One of the analogs, LL-66, localizes to the mitochondria and is absent from the nucleus in isolated adult rat cardiac myocytes. Inhibiting activity of HDAC1 dur...
Published: 8/22/2017   |   Inventor(s): Donald Menick, Chung-Jen (James) Chou, Daniel Herr, Xiaoyang Li
Keywords(s):  
Category(s): Therapeutic
Novel class I HDAC inhibitors that are impervious to glucuronidation for the treatment of hematologic malignancies and inflammatory diseases/disorders
Novel class I HDAC inhibitors that are impervious to glucuronidation for the treatment of hematologic malignancies and inflammatory diseases/disordersTechnology: MUSC researchers have developed a series of potent and selective class I histone deacetylase (HDAC) inhibitors that do not suffer from the genotoxicity, off-target effects, and metabolic ...
Published: 2/1/2017   |   Inventor(s): Chung-Jen (James) Chou, Jesse Mcclure, Cheng Zhang, Elizabeth Inks
Keywords(s):  
Category(s): Therapeutic
Therapeutics for Epilepsy and other Neurological Disorders
Technology: The inventors discovered a novel non-toxic agent that attenuates seizure activity in two animal models of epilepsy. This agent is a highly potent Vitamin K analogue that was first identified in a chemical screen using a zebrafish model of epilepsy (Figure 1). This agent was further tested in several mouse models of epilepsy, performed a...
Published: 3/27/2013   |   Inventor(s): Chung-Jen (James) Chou, Sherine Chan, Jennifer Rahn, Benjamin Josey
Keywords(s): neurological
Category(s): Therapeutic
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