Search Results - chung-jen+(james)+chou

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Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis

Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic Diseases Technology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized...

Published: 3/23/2023 | Inventor(s): Chung-Jen (James) Chou, Ying Mei, Jia Jia

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Category(s): BioPharma

Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)

Technology: Researchers at MUSC have discovered HDAC1 is present in the adult cardiac myocyte mitochondria. A series of HDAC1 inhibitors that target mitochondria have been made (MitoDACs). One of the analogs, LL-66, localizes to the mitochondria and is absent from the nucleus in isolated adult rat cardiac myocytes. Inhibiting activity of HDAC1...

Published: 3/22/2023 | Inventor(s): Donald Menick, Chung-Jen (James) Chou, Daniel Herr, Xiaoyang (李晓杨) Li

Keywords(s):

Category(s): BioPharma