Search Results - donald+menick

2 Results

Sort By:

Electrically Conductive Nanomaterials Reinforced Cardiac Microtissues

Technology: Progenitor cells provide strong regenerative ability, but are limited by their immature phenotype and inability to generate functional tissues equivalent to adult cardiomyocytes. This technology provides a novel approach to successfully regenerate functional cardiomyocytes from progenitor cells. The strategy involves providing a physiologically-relevant...

Published: 3/22/2023 | Inventor(s): Donald Menick, Ying Mei, Tan Yu, Dylan Richards, Bozhi Tian

Keywords(s):

Category(s): BioPharma

Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)

Technology: Researchers at MUSC have discovered HDAC1 is present in the adult cardiac myocyte mitochondria. A series of HDAC1 inhibitors that target mitochondria have been made (MitoDACs). One of the analogs, LL-66, localizes to the mitochondria and is absent from the nucleus in isolated adult rat cardiac myocytes. Inhibiting activity of HDAC1...

Published: 4/29/2024 | Inventor(s): Donald Menick, Chung-Jen (James) Chou, Daniel Herr, Xiaoyang (李晓杨) Li

Keywords(s):

Category(s): BioPharma