Search Results - donald menick

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Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)
Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)Technology: Researchers at MUSC have discovered HDAC1 is present in the adult cardiac myocyte mitochondria. A series of HDAC1 inhibitors that target mitochondria have been made (MitoDACs). One of the analogs, LL-66, localizes to th...
Published: 8/22/2017   |   Inventor(s): Donald Menick, Chung-jen (james) Chou, Daniel Herr, Xiaoyang Li
Keywords(s):  
Category(s): Therapeutic
Electrically Conductive Nanomaterials Reinforced Cardiac Microtissues
Technology: Progenitor cells provide strong regenerative ability, but are limited by their immature phenotype and inability to generate functional tissues equivalent to adult cardiomyocytes. This technology provides a novel approach to successfully regenerate functional cardiomyocytes from progenitor cells. The strategy involves providing a physiol...
Published: 3/24/2015   |   Inventor(s): Donald Menick, Ying Mei, Tan Yu, Dylan Richards, Bozhi Tian
Keywords(s):  
Category(s): Research Tool
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