Search Results - diagnostic

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Biomarkers for Detecting Diastolic Heart Failure
The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies patients with early-stage changes that are indicative of heart failure. These biomarkers can be detected and measured by performing a simple, point-of-care blood test and pro...
Published: 2/25/2013   |   Inventor(s): Francis Spinale, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Predicting Left Ventricular Dilation following Myocardial Infarction by Protease and Protease Inhibitor Profiling
Technology: This invention relates to a method of predicting diastolic heart failure in a patient, by identifying, from their body fluid, a profile of MMPs and TIMPs that is associated with the development of left ventricular dilation (LVD). This biomarker panel can identify these patients shortly (1-5 days) after their infarct occurs.Overview:Worl...
Published: 2/25/2013   |   Inventor(s): Francis Spinale, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Biomarkers for Detecting and Monitoring Aortic Aneurysms
The inventors have developed a highly specific and sensitive panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which identifies and follows the progression of thoracic aortic aneurysm in patients. These biomarkers can be detected and measured by performing a simple, point...
Published: 2/18/2013   |   Inventor(s): John Ikonomidis, Jeffrey Jones, Rupak Mukherjee, Robert Stroud, Michael Zile
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Plasma Biomarkers for Predicting Recurrence of Atrial Fibrillation Following Cardioversion
The inventors have developed a panel of biomarkers, including various matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs), which can determine patients at risk for recurrent atrial fibrillation (AF). These biomarkers can pre-emptively detect treatment failure for cardioversion activities. These biomarkers can be ...
Published: 6/12/2012   |   Inventor(s): Rupak Mukherjee, Michael Gold, Francis Spinale
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Assessing Left Ventricular Remodeling via Temporal Detection and Measurement of microRNA in Body Fluids
This invention provides a method of assessing cardiac disease including thoracic aortic aneurysm (TAA) and left ventricular (LV) remodeling by measuring the levels of 5 microRNAs (miRs) in a body fluid such as plasma or serum, or in cardiac and aortic tissue. miRs are small noncoding RNAs that recognize and bind to mRNA and inhibit protein translat...
Published: 3/8/2012   |   Inventor(s): Francis Spinale, Michael Zile, Robert Stroud
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Biomarkers for the Detection and Monitoring of Coronary Artery Disease
Technology: The inventors have developed a methodology that has been robustly validated (~800 patients) to accurately and reliably measure Ox-LDL, AGE-LDL and other modified LDLs circulating in bound/immune-complex (IC) form. The method involves isolation of IC from blood samples and fractionation of the isolated IC in order to separate modified fo...
Published: 4/19/2011   |   Inventor(s): Maria LopeS-Virella, Gabriel Virella
Keywords(s): cardiovascular, diagnostic
Category(s): Diagnostic
Biomarker for the Detection and Monitoring of Bladder Cancer
The inventors have developed a biomarker application based on thromboxane receptor β (TPβ), which identifies patients with various stages of bladder cancers (invasive, superficial, or metastatic). TPβ proteins are overexpressed in common bladder tumor tissue but not normal human cells. Human urine samples of patients positive for var...
Published: 3/27/2011   |   Inventor(s): Omar Moussa, Dennis Watson, Perry Halushka
Keywords(s): cancer, diagnostic, genitourinary
Category(s): Diagnostic
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