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MUSC Oncology Therapeutics: Liposomal Delivery of Encapsulated Therapeutics to Treat Pediatric Brain Tumorshttp://musc.technologypublisher.com/technology/17463 LSD1 Protein Inhibitors as Epigenetic Modulatorshttp://musc.technologypublisher.com/technology/15182 Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1)http://musc.technologypublisher.com/technology/15181 Chaperone-based...

Published: 2/7/2023 | Inventor(s):

Keywords(s): cancer

Category(s): BioPharma

Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1)

Technology: Researchers at MUSC have used a ligand-based approach to design and synthesize a series of cyclic peptides that are effective inhibitors of LSD1, and have greater stability to proteolytic degradation than their linear homologues. Cyclic peptide 9 inhibits LSD1 in vitro with a Ki value of 385 nM, and has antitumor activity in MCF-7 and Calu-6...

Published: 4/25/2023 | Inventor(s): Patrick Woster, Isuru Kumarasinghe

Keywords(s): cancer

Category(s): BioPharma

Biomarker for the Detection and Monitoring of Bladder Cancer

The inventors have developed a biomarker application based on thromboxane receptor β (TPβ), which identifies patients with various stages of bladder cancers (invasive, superficial, or metastatic). TPβ proteins are overexpressed in common bladder tumor tissue but not normal human cells. Human urine samples of patients positive for various...

Published: 12/20/2023 | Inventor(s): Omar Moussa, Dennis Watson, Perry Halushka

Keywords(s): cancer, diagnostic, genitourinary

Category(s): BioPharma