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Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1)

Technology: Researchers at MUSC have used a ligand-based approach to design and synthesize a series of cyclic peptides that are effective inhibitors of LSD1, and have greater stability to proteolytic degradation than their linear homologues. Cyclic peptide 9 inhibits LSD1 in vitro with a Ki value of 385 nM, and has antitumor activity in MCF-7 and Calu-6...

Published: 4/25/2023 | Inventor(s): Patrick Woster, Isuru Kumarasinghe

Keywords(s): cancer

Category(s): BioPharma