Search Results - patrick+woster

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LSD1 Protein Inhibitors as Fetal Hemoglobin Inducers for Sickle Cell Disease

Technology: Researchers at MUSC have identified several potential inhibitors of lysine-specific demethylase 1 (LSD1) utilizing a virtual screen and found compounds that fit the LSD1 active site in silico. Next, they synthesized these molecules and evaluated them as highly selective LSD1 inhibitors. The series of compounds are new chemical entities being...

Published: 4/7/2023 | Inventor(s): Patrick Woster, Craig Kutz

Keywords(s):

Category(s): BioPharma

Non-Aniline Histone Deacetylase Inhibitors

Technology: Inventors at MUSC have discovered a 2-(oxazol-2-yl)phenol moiety containing a novel zinc binding group (ZBG) that can be used to produce compounds that are potent histone deacetylase (HDAC) inhibitors. A series of 15 analogues with the novel ZBG have been synthesized, and exhibit selective inhibition against HDAC1 as well as HDAC 6 &...

Published: 4/25/2023 | Inventor(s): Patrick Woster, Youxuan Li

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Category(s): BioPharma

LSD1 Protein Inhibitors as Cancer Therapeutics

Technology: Researchers at MUSC have identified several potential inhibitors of lysine-specific demethylase 1 (LSD1) utilizing a virtual screen and found compounds that fit the LSD1 active site in silico. LSD1 is overexposed in a number of human cancers (neuroblastoma, retinoblastoma, prostate, cancer, lung, and bladder), and has emerged as an important...

Published: 4/25/2023 | Inventor(s): Patrick Woster, Craig Kutz

Keywords(s):

Category(s): BioPharma

Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1)

Technology: Researchers at MUSC have used a ligand-based approach to design and synthesize a series of cyclic peptides that are effective inhibitors of LSD1, and have greater stability to proteolytic degradation than their linear homologues. Cyclic peptide 9 inhibits LSD1 in vitro with a Ki value of 385 nM, and has antitumor activity in MCF-7 and Calu-6...

Published: 4/25/2023 | Inventor(s): Patrick Woster, Isuru Kumarasinghe

Keywords(s): cancer

Category(s): BioPharma