Search Results - patrick+woster

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Non-Aniline Histone Deacetylase Inhibitors

Technology: Inventors at MUSC have discovered a 2-(oxazol-2-yl)phenol moiety containing a novel zinc binding group (ZBG) that can be used to produce compounds that are potent histone deacetylase (HDAC) inhibitors. A series of 15 analogues with the novel ZBG have been synthesized, and exhibit selective inhibition against HDAC1 as well as HDAC 6 &...

Published: 4/25/2023 | Updated: 3/24/2015 | Inventor(s): Patrick Woster, Youxuan Li

Keywords(s):

Category(s): BioPharma

Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1)

Technology: Researchers at MUSC have used a ligand-based approach to design and synthesize a series of cyclic peptides that are effective inhibitors of LSD1, and have greater stability to proteolytic degradation than their linear homologues. Cyclic peptide 9 inhibits LSD1 in vitro with a Ki value of 385 nM, and has antitumor activity in MCF-7 and Calu-6...

Published: 4/25/2023 | Updated: 5/13/2014 | Inventor(s): Patrick Woster, Isuru Kumarasinghe

Keywords(s): cancer

Category(s): BioPharma