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Non-Aniline Histone Deacetylase Inhibitors

Technology: Inventors at MUSC have discovered a 2-(oxazol-2-yl)phenol moiety containing a novel zinc binding group (ZBG) that can be used to produce compounds that are potent histone deacetylase (HDAC) inhibitors. A series of 15 analogues with the novel ZBG have been synthesized, and exhibit selective inhibition against HDAC1 as well as HDAC 6 &...

Published: 4/25/2023 | Inventor(s): Patrick Woster, Youxuan Li

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Category(s): BioPharma