Description:
Technology: Inventors at MUSC have discovered a 2-(oxazol-2-yl)phenol moiety containing a novel zinc binding group (ZBG) that can be used to produce compounds that are potent histone deacetylase (HDAC) inhibitors. A series of 15 analogues with the novel ZBG have been synthesized, and exhibit selective inhibition against HDAC1 as well as HDAC 6 & HDAC10. Compound 10 possesses an IC50 value of 7.5 μM in the MV-4-11 leukemia cell line, and induces a comparable amount of acetylated histone 3 lysine 9 (H3K9) and p21Waf1/CIP1 as 0.5 μM of SAHA. Modeling of compound 10 in the active site of HDAC2 demonstrates that it has a zinc-binding pattern similar to benzamide HDAC inhibitors, but does not contain an aniline moiety that can potentially generate toxic metabolites in vivo. Additionally, the HDAC inhibitor base structure can be synthesized via a facile one-pot reaction procedure that is highly amenable to compound library development.
![](data:image/png;base64,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)
Overview: HDAC inhibitors have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics, and are recently being investigated as possible treatments for cancers as well as parasitic and inflammatory diseases. HDACs are considered highly attractive targets for cancer drug discovery. The hyperacetylation induced by HDAC inhibitors leads to changes in gene expression and functional modifications of non-histone proteins, thereby triggering antitumor pathways. Small molecules featuring a hydroxamic acid or benzamide ZBG have been the most commonly studied HDAC inhibitors to date. However, concerns about the pharmacokinetic liabilities of the hydroxamic acid moiety and potential metabolic toxicity of the aniline portion of the benzamide HDAC inhibitors have stimulated research to discover alternative ZBGs.
Advantages: Structurally the same as benzamide HDACs without the aniline moiety that generates toxic metabolites in vivo.
Key Words: Zinc binding group, gene expression modification, cancer, histone deacetylase inhibitor, drug discovery
Publications: Li, Youxuan, and Patrick M. Woster. "Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group." MedChemComm (2015).
Inventors: Patrick M. Woster & Youxuan Li
Patent Status: US 10,000,474
MUSC-FRD Technology ID: P1504