Search Results - Therapeutic

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Small molecule inhibitor EN460 to modulate T cell metabolism to augment cancer immunotherapy
Technology: A MUSC researcher has identified a novel immune-based therapy to treat cancer by targeting the PERK pathway using ERO1α antagonists combined with immune checkpoint blockade or Adoptive T-Cell (ACT) therapies. Data gathered demonstrates that either a PERK or ERO1α inhibitor combined with anti-PD-1 or ACT has a superior therap...
Published: 3/23/2019   |   Inventor(s): Jessica Thaxton
Keywords(s):  
Category(s): Therapeutic
A new class of alkaloids with potent and selective targeting of pancreatic cancer in vitro
Technology: Inventors from MUSC have identified a class of brominated alkaloid compounds, including aleutianamine, which has potent bioactivity across multiple cancer cell lines in vitro. Extraction and purification of specimens of Latrunculia austini, led to isolation of a potential target mass m/z 398 that resulted from MS/MS molecular ion networ...
Published: 3/18/2019   |   Inventor(s): Mark Hamann, Fred Valeriote
Keywords(s):  
Category(s): Therapeutic
A Method for Tissue-Engineering Organ Building Blocks
Technology: Researchers from MUSC and University of South Carolina have developed a new method for generating tissue-engineered rings (toroids) of aligned contractile cells. The novel approach provides self-organized morphogenetic principles that may be used as a 3D blood vessel construction or wound healing enhancer (figure 1). Figure 1. Hypothe...
Published: 3/1/2019   |   Inventor(s): Robert Gourdie, Jay Potts
Keywords(s):  
Category(s): Therapeutic
A new class of natural products with a unique ring system was identified with hepatoprotective activity and the for use in the control of liver disease and its progression to cancer or cirrhosis.
Technology: MUSC inventors have identified a new class of natural compounds with a unique ring system that possess hepatoprotective activity for use in control of liver disease such as cancer or cirrhosis, and liver damage induced by toxins. Kadsuraol A-C (compounds 1-3), are three highly modified tetrahydrocyclobutaphenanthrofuranone-type lignans ...
Published: 2/20/2019   |   Inventor(s): Mark Hamann, Xiaojuan Wang
Keywords(s):  
Category(s): Therapeutic
Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCR)
Pathologies associated with Luteinizing hormone-releasing hormone LHRH include a number of cancers, prostate hyperplasia, endometriosis, uterine fibroids and polycystic ovary syndrome. Analogues for LHRH have been developed to treat gynecological disorders and cancers, including leuprolide and triptorelin. However, agonists of LHRH lead to total ph...
Published: 9/17/2018   |   Inventor(s): Klaus Paulini, Matthias Gerlach, Eckhard Guenther, Emmanuel Polymeropoulos, Silke Baasner, Peter Schmidt, Ronald Kuhne, Arvid Soderhall
Keywords(s):  
Category(s): Therapeutic
Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis
Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic DiseasesTechnology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized h...
Published: 9/6/2018   |   Inventor(s): Chung-Jen (James) Chou, Ying Mei, Jia Jia
Keywords(s):  
Category(s): Therapeutic
Glyco-Typer- A method of glycan analysis of immunocaptured proteins
Glyco-Typer- A method of glycan analysis of immunocaptured proteinsTechnology: Researchers at the Medical University of South Carolina have created a method and system that for the first time will enable the simultaneous glycan analysis of thousands of individual proteins found in complex protein mixtures such a serum and tissue samples. This metho...
Published: 8/2/2018   |   Inventor(s): Anand Mehta, Richard Drake, Brian Haab
Keywords(s):  
Category(s): Therapeutic
5HT1F receptor ligands that induce mitochondrial biogenesis
Technology: MUSC investigators have synthesized new chemical entity analogues for 5HT1F receptors. These structurally unique novel chemical entities act as agonists to the serotonin class-1F (5HT1F) receptors and were found to be potent inducers of mitochondrial biogenesis (MB) in vitro. Also, several of the compounds were tested and found to indu...
Published: 6/27/2018   |   Inventor(s): Christopher Lindsey, Craig Beeson, Rick Schnellmann, Yuri Peterson
Keywords(s):  
Category(s): Therapeutic
Organ Preconditioning with Mitochondrial Elongating Agents M1/Mdivi1 in Transplantation
M1/Mdivi1 as a novel treatment to reduce immunogenicity in organ transplantationTechnology: Addition of M1 and Mdivi1 drugs in organ preservation solutions can reduce the immunogenicity of the donor organ’s microvascular endothelial cells (ECs), thereby promoting allograft immune tolerance. Inventors at MUSC have found that the use of M1 (a m...
Published: 3/19/2018   |   Inventor(s): Satish Nadig, Carl Atkinson, Danh Tran
Keywords(s):  
Category(s): Therapeutic
Total Body Irradiation Using Pre-Existing Dose Dynamic Fields
Technology: TA library of pre-commissioned dose dynamic fields offers a simple method for delivery of total body irradiation (TBI) given in preparation for transplant. This simple technique is available for any VMAT-capable machine, regardless of the treatment room size or span of the MLCs, yet does not require complex planning or patient-specific ...
Published: 10/9/2017   |   Inventor(s): Nicholas Koch
Keywords(s):  
Category(s): Therapeutic
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