Search Results - Therapeutic

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Chamber for Cyroprotectant Tissues Perfusion and Bioengineered Tissue Scaffolds
The chamber is for use in the rapid stabilization of cell viability and tissue architecture post tissue freezing and thawing. These chambers were created to address the inefficiencies of the syringe-only approach surrounding the proprietary cryoprotectant and perfusion protocol (CPP). There are currently three perfusion chamber systems: 1) a &lsqu...
Published: 11/6/2017   |   Inventor(s): John Baatz, Demetri D. Spyropoulos
Keywords(s):  
Category(s): Therapeutic
Dopamine Gene Variants Predict Response to Aripiprazole in Individuals
Technology: Since medications that can control, regulate, or change the brain dopamine system might be beneficial in treating Alcohol Use Disorder (AUD), MUSC investigators studied the anti-drinking effect of a marketed brain dopamine acting medication, aripiprazole, in individuals with AUD who were genotyped for variants in several brain-functiona...
Published: 10/13/2017   |   Inventor(s): Raymond Anton, Joseph Schacht
Keywords(s):  
Category(s): Therapeutic
The Combination of Two Genetic Variants Can Predict Response to Naltrexone in Individuals with Alcohol Use Disorder (AUD)
Technology: Researchers at MUSC have identified multiple gene variants that are critical for the response to opioid receptor antagonists, including naltrexone for AUD. First, recent work has further validated that carriers of OPRM1 asp40/ DAT10 variable number tandem repeat (VNTR) and asn40/ DAT9 variant carriers do better on naltrexone than other ...
Published: 10/13/2017   |   Inventor(s): Raymond Anton
Keywords(s):  
Category(s): Therapeutic
Total Body Irradiation Using Pre-Existing Dose Dynamic Fields
Technology: TA library of pre-commissioned dose dynamic fields offers a simple method for delivery of total body irradiation (TBI) given in preparation for transplant. This simple technique is available for any VMAT-capable machine, regardless of the treatment room size or span of the MLCs, yet does not require complex planning or patient-specific ...
Published: 10/9/2017   |   Inventor(s): Nicholas Koch
Keywords(s):  
Category(s): Therapeutic
Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1- Sickle Cell Disease
Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 (LSD1) for Sickle Cell Disease Technology: Researchers at MUSC have used a ligand-based approach to design and synthesize a series of cyclic peptides that are effective inhibitors of LSD1, and have greater stability to proteolytic degradation than their linear homologues. For example, cycli...
Published: 9/13/2017   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)
Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)Technology: Researchers at MUSC have discovered HDAC1 is present in the adult cardiac myocyte mitochondria. A series of HDAC1 inhibitors that target mitochondria have been made (MitoDACs). One of the analog, LL-66, localizes to the...
Published: 8/22/2017   |   Inventor(s): Donald Menick, Chung-Jen (James) Chou, Daniel Herr, Xiaoyang Li
Keywords(s):  
Category(s): Therapeutic
Pharmaceuticaly Modified T cells for Adoptive Cell Therapy Against Cancer
Inventors have found that treatment of tumor-reactive human T cells with drugs that co-modulate β-catenin and PI3Kδ enhances their antitumor capacity, especially their ability to exert a long-term immune response against cancer. Th17 cells inhibited of both pathways expressed less RORγt, which, in turn, reduced their ability to sec...
Published: 7/10/2017   |   Inventor(s): Chrystal Paulos, Kinga Majchrzak, Jacob Bowers
Keywords(s):  
Category(s): Therapeutic
Antifibrotic effects of oxetanyl sulfoxides
Currently, there are only two approved therapies for Idiopathic Pulmonary Fibrosis (IPF), pirfenidone and nintedanib, which are minimally effective at slowing the disease. These treatments are not effective at all in halting or reversing the progression of IPF. Therefore, there remains a great need for more effective therapies. Researchers at MUSC ...
Published: 6/14/2017   |   Inventor(s): Carol Feghali-Bostwick, Peter Wipf
Keywords(s):  
Category(s): Therapeutic
Delivery of chemotherapeutics to brain tumors
Brain cancer is a life-threatening disease with a poor prognosis. This includes Glioblastoma Multiform (GBM), which has a standard treatment of surgical resection, radiation therapy and concurrent chemotherapy with temozolomide (TMZ). The median survival is 14 months because surgeons are unable to completely remove GBM, radiation does not completel...
Published: 5/18/2017   |   Inventor(s): Ann-Marie Broome, Suraj Dixit, Amy-Lee Bredlau
Keywords(s):  
Category(s): Therapeutic
Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCR)
Pathologies associated with Luteinizing hormone-releasing hormone LHRH include a number of cancers, prostate hyperplasia, endometriosis, uterine fibroids and polycystic ovary syndrome. Analogues for LHRH have been developed to treat gynecological disorders and cancers, including leuprolide and triptorelin. However, agonists of LHRH lead to total ph...
Published: 5/16/2017   |   Inventor(s): Klaus Paulini, Matthias Gerlach, Eckhard Guenther, Emmanuel Polymeropoulos, Silke Baasner, Peter Schmidt, Ronald Kuhne, Arvid Soderhall
Keywords(s):  
Category(s): Therapeutic
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