Search Results - christopher+davies

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N-aroylanthranilic acids and derivatives as inhibitors of bacterial class B transpeptidases
Technology: MUSC inventors identified a new chemical scaffold (N-aroylanthranilic acids and derivatives) as inhibitors of various class B penicillin-binding proteins (PBPs). The novel molecules showed high potency of PBP inhibition. Antimicrobial assays against antibiotic-resistant gonorrhea strain FA19 and H041 showed significant growth inhibition...
Published: 11/9/2020   |   Inventor(s): Jonathan Turner, Christopher Davies, Patrick Woster, Joy Kirkpatrick
Keywords(s):  
Category(s): Therapeutic
High-Throughput Screening Assay for Novel Inhibitors of Penicillin Binding Proteins
Researchers at MUSC have developed a high-throughput assay that uses fluorescence polarization (FP) to distinguish the fluorescent penicillin, Bocillin-FL, in free or PBP-bound form. The assay can be used to identify new compounds that inhibit penicillin binding proteins (PBPs), which are proven targets for β-lactam antibiotics. This assay was...
Published: 5/20/2014   |   Inventor(s): Christopher Davies, Alena Fedarovich, Yuri Peterson
Keywords(s): infectious
Category(s): Therapeutic
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