Search Results - yuri peterson

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5HT1F receptor ligands that induce mitochondrial biogenesis
Technology: MUSC investigators have used manual curation and traditional medicinal chemistry techniques to synthesize new chemical entity analogues for 5HT1F receptors. These structurally unique novel chemical entities act as agonists to the serotonin class-1F (5HT1F) receptors and were found to be potent inducers of mitochondrial biogenesis (MB) i...
Published: 6/27/2018   |   Inventor(s): Christopher Lindsey, Craig Beeson, Rick Schnellmann, Yuri Peterson
Keywords(s):  
Category(s): Therapeutic
High-Throughput Screening Assay for Novel Inhibitors of Penicillin Binding Proteins
Researchers at MUSC have developed a high-throughput assay that uses fluorescence polarization (FP) to distinguish the fluorescent penicillin, Bocillin-FL, in free or PBP-bound form. The assay can be used to identify new compounds that inhibit penicillin binding proteins (PBPs), which are proven targets for β-lactam antibiotics. This assay wa...
Published: 5/20/2014   |   Inventor(s): Christopher Davies, Alena Fedarovich, Yuri Peterson
Keywords(s): infectious
Category(s): Therapeutic
MitoMoby Mitochondrial Morphology Analysis Software
MitoMoby is a high throughput and high content microscopic method for the analysis of mitochondrial morphology (MM) and membrane potential. MitoMoby delineates a procedure for MM analysis using the R platform for data analysis, annotation, and image registration and GE INCell Investigator (specifically, the GE INCell Developer Toolbox package) plat...
Published: 3/19/2014   |   Inventor(s): Craig Beeson, Baerbel Rohrer, Anthony Leonard, Rick Schnellmann, Bethany Wolf, Jaime Speiser, Robert Cameron, Yuri Peterson
Keywords(s):  
Category(s): Software, Research Tool
DotQuanta Endosome Quantifying Software
Researchers at MUSC have configured a robust, platform-independent algorithm for use of real-time quantification of receptor endosome formation, agonist mobilization, co-localization, areas, and shapes. The algorithm works by segmenting the cells, localizing fluorescently stained nuclei to the segmented outlines, counting the number of small object...
Published: 10/21/2013   |   Inventor(s): Yuri Peterson, Sherwin Soltani, Kathryn Appleton, Anthony Leonard
Keywords(s):  
Category(s): Software, Research Tool
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