Search Results - therapeutic

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Blocking GARP (LRRC32) cleavage and Its Application in Immunotherapy
Technology: Researchers at MUSC have developed a method and peptide composition (the “T250 peptide”) for treating cancer by inhibiting Glycoprotein-A Repetitions Predominant Protein (GARP) cleavage and thus impeding the activation of Transforming Growth Factor-Beta (TGF-β) – a growth factor that suppresses T-cell mediated anti-cancer...
Published: 9/23/2019   |   Inventor(s): Zihai Li
Keywords(s):  
Category(s): Therapeutic
Combination Therapy with Mesenchymal Stem Cells and the Caveolin-1 Scaffolding Domain Peptide as a Novel Therapy for Systemic Sclerosis
Technology: MUSC researchers propose a novel therapy for systemic sclerosis (SSc) combining autologous patient-derived mesenchymal stem cells (MSCs) and the caveolin-1 scaffolding domain peptide (CSD). In a mouse model, this combination significantly improved the efficacy of MSC therapy compared to MSCs alone. Researchers have previously shown efficacy...
Published: 9/10/2019   |   Inventor(s): Elena Tourkina, Stanley Hoffman, Nicoletta Del Papa
Keywords(s):  
Category(s): Therapeutic
Endothelial Progenitor Cell-Derived Exosomes as a Novel Therapeutic in Sepsis
Technology: MUSC researchers have developed a novel therapy to treat sepsis and Acute Respiratory Distress Syndrome (ARDS) using endothelial progenitor cell-derived (EPC) exosomes, which reduced lung and organ injury, inflammation response, and increased survival rate in a mouse model. Data gathered showed that in a sepsis model, IV administration of...
Published: 8/20/2019   |   Inventor(s): Hongkuan Fan, Andrew Goodwin, Perry Halushka, James Cook, Yue Zhou, Pengfei Li
Keywords(s):  
Category(s): Therapeutic
Inhibition of the Histone Demethylase KDM4B Leads to Activation of KDM1A, Attenuates Bacterial-Induced Pro-Inflammatory Cytokine Release and Reduces Osteoclastogenesis
Technology: Researchers at MUSC have discovered a series of novel small molecules that contain potent immunosuppressive activity and can be used as the new treatment for periodontal disease (PD). PD is caused by bacteria infection in dental plaque, which leads to the inflammation response in the area of gums, periodontal ligament or alveolar bone....
Published: 8/13/2019   |   Inventor(s): Patrick Woster, Joy Kirkpatrick
Keywords(s):  
Category(s): Therapeutic
Motion-Activated, Closed-loop Non-invasive Vagus Nerve Stimulation as a Neurorehabilitation Tool
Technology: Surgeons and researchers at MUSC have created a non-invasive, motion-activated, closed-loop vagus nerve simulation (VNS) device that enhances neuroplasticity to accelerate motor restoration in post-stroke rehabilitation. The device couples VNS with limb motion to provide stimulation simultaneously with movement, enhancing the effects of...
Published: 8/9/2019   |   Inventor(s): Bashar Badran, Mark George
Keywords(s):  
Category(s): Therapeutic
Delivery of CR2-fH complement inhibitors using gene therapy as novel treatment for age-related macular degeneration (AMD)
Technology: A group of MUSC researchers have developed a novel gene therapy technique to treat age-related macular degeneration (AMD) pathogeneis by introducing a novel complement inhibitory funsion protein (CR2-fH) via an adeno-associated virus (AAV). Data gathered showed that after subretinal delivery of AAV-VMD2-CR2-fH in C57BL/6J mice, the secretion...
Published: 6/21/2019   |   Inventor(s): Monica Vetter, Alejandra Bosco, Baerbel Rohrer
Keywords(s):  
Category(s): Therapeutic
Applying PERK/ERO1α inhibitors to modulate T cell metabolism to augment cancer immunotherapy
Technology: A MUSC researcher has identified a novel immune-based therapy to treat cancer by targeting the PERK pathway using ERO1α antagonists combined with immune checkpoint blockade or Adoptive T-Cell (ACT) therapies. Data gathered demonstrates that either a PERK or ERO1α inhibitor combined with anti-PD-1 or ACT has a superior therapeutic...
Published: 3/23/2019   |   Inventor(s): Jessica Thaxton
Keywords(s):  
Category(s): Therapeutic
A new class of alkaloids with potent and selective targeting of pancreatic cancer in vitro
Technology: Inventors from MUSC have identified a class of brominated alkaloid compounds, including aleutianamine, which has potent bioactivity across multiple cancer cell lines in vitro. Extraction and purification of specimens of Latrunculia austini, led to isolation of a potential target mass m/z 398 that resulted from MS/MS molecular ion networking-MoIN...
Published: 3/18/2019   |   Inventor(s): Mark Hamann, Fred Valeriote
Keywords(s):  
Category(s): Therapeutic
A Method for Tissue-Engineering Organ Building Blocks
Technology: Researchers from MUSC and University of South Carolina have developed a new method for generating tissue-engineered rings (toroids) of aligned contractile cells. The novel approach provides self-organized morphogenetic principles that may be used as a 3D blood vessel construction or wound healing enhancer (figure 1). Figure 1. Hypothetical...
Published: 3/1/2019   |   Inventor(s): Robert Gourdie, Jay Potts
Keywords(s):  
Category(s): Therapeutic
A new class of natural products with a unique ring system was identified with hepatoprotective activity and the for use in the control of liver disease and its progression to cancer or cirrhosis.
Technology: MUSC inventors have identified a new class of natural compounds with a unique ring system that possess hepatoprotective activity for use in control of liver disease such as cancer or cirrhosis, and liver damage induced by toxins. Kadsuraol A-C (compounds 1-3), are three highly modified tetrahydrocyclobutaphenanthrofuranone-type lignans with...
Published: 2/20/2019   |   Inventor(s): Mark Hamann, Xiaojuan Wang
Keywords(s):  
Category(s): Therapeutic
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