Search Results - therapeutic

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Disclosed are compositions and methods of using recombinant CD59, to inhibit complement activity. The complement system is a component of the innate immunity that helps clear pathogens from an organism. CD59 is a membrane-bound protein that can inhibit the formation of the membrane attack complex (MAC), the terminal and potentially cytotoxic prod...

Published: Jun 14, 2013 | Inventor(s): Stephen Tomlinson

Keywords(s):

Category(s): Therapeutic

Compounds for Induction of Mitochondrial Biogenesis

Technology: The inventors have identified a series of compounds that induce mitochondrial biogenesis. These compounds cause the activation of the peroxisome proliferator-activated receptor gamma coactivator-1a, the regulator of mitochondrial biogenesis. By activating biogenesis, mitochondria can correct impairments or increase mitochondrial c...

Published: Mar 27, 2013 | Inventor(s): Craig Beeson, Rick Schnellmann, Yuri Peterson, Lauren Wills

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Category(s): Therapeutic

Novel compounds for neuroprotection and epilepsy

Technology: The inventors discovered a compound that protects neuronal HT-22 cells from glutamate excitotoxicity. These vitamin K derivatives prevent programmed cell death associated with oxidative stress in neurons and oligondentrocytes. These derivatives can be used in therapies for neurodegenerative disease, stroke, traumatic brain injury,...

Published: Mar 27, 2013 | Inventor(s): Chung-Jen (James) Chou, Sherine Chan, Jennifer Rahn, Benjamin Josey

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Category(s): Therapeutic

Combined Use of Cystine-Glutamate Exchange Activator and MGluR5 Antagonist for Treating Addiction

Addiction and addictive behavior continues to plague individuals. While numerous advances in psychosocial and pharmaco therapies have been made, prevention or reduction of relapse of addictive behavior continues to remain elusive. Recent advances in the understanding of the neurophysiological roles of mGluRs have established these receptors as prom...

Published: Feb 18, 2013 | Inventor(s): Peter Kalivas, Khaled Moussawi, Robert Malcolm

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Category(s): Therapeutic

Nanoparticle for Targeted Delivery of Topical Therapies to the Respiratory Tract

Description: The delivery of therapeutics to the nasal track is still relatively problematic. While there are a number of inhalants and other delivery mechanisms, they do not provide quick or immediate effects of the drugs. The present technology provides nanoparticles that are engineered to include both specific targeting antibodies and a the...

Published: Aug 30, 2012 | Inventor(s): Rodney Schlosser, Alexey Vertegel, Carl Atkinson

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Category(s): Therapeutic

Nucleosides Analogs for Cardiovascular and Neurodegenerative Diseases

Technology: The inventors have developed a synthetic, L-adenosine analog that mimics the natural nucleoside and binds competitively to adenosine receptors. The specificity of this analog for a range of adenosine receptors makes it uniquely suited for the study and potential treatment of cardiovascular and neurodegenerative diseases. Overvie...

Published: Aug 30, 2012 | Inventor(s): Giuseppe Gumina, Craig Beeson, Gary Wright

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Category(s): Therapeutic

Tissue Targeted Complement Modulators

Technology: The inventors have developed novel compositions of complement inhibitors that are targeted to the proximal tubular epithelial that have been shown to protect against tubulointerstitial injury and renal dysfunction in a rat model of nephrosis. This targeting of the inhibitors at a specific site of disease was shown to increase the e...

Published: Aug 30, 2012 | Inventor(s): Stephen Tomlinson, Richard Quigg

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Category(s): Therapeutic

New antimicrobials against Neisseria Gonorrhea

Technology: A screen of 50,000 compounds in the DIVERSet library from the Chembridge Corporation has identified 25 compounds with activity against the penicillin-binding protein 2 (penA, PBP2) and had micromolar activities against various strains of drug-resistant N. gonorrhoeae (FA19, FA610 and 35/02). These new compounds show promise as no...

Published: Aug 30, 2012 | Inventor(s): Christopher Davies, Alena Fedarovich

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Category(s): Therapeutic

Compositions, Methods and Kits for Treating Cancers Associated with a Virus

Technology: The technology provided includes therapeutic compositions, methods and kits for the treatment of the viral-associated and chemoresistant lymphoma, Primary Effusion Lymphoma (PEL). The technology capitalizes on the recognition that emmprin (CD147), the lymphatic vessel endothelial hyaluronan receptor (LYVE-1) and a drug transporter...

Published: Jun 18, 2012 | Inventor(s): Bryan Toole, Christopher Parsons

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Category(s): Therapeutic

Targeting Subventricular Zone Progenitor Cells with Intrathecal Liposomal Encapsulated Ara-C (DepoCyt) in Patients with Glioblastoma Multiforme

Despite significant increases in recognition and treatment options for Gliomas, such as glioblastoma multiform, the median survival for glioma patients is 12-18 months. The present technology provides compostions and methods that increase activity against gliomas that utilize combinations of cytarabine therapeutics and diuretics in a co-treatment. ...

Published: Jun 18, 2012 | Inventor(s): Bruce Frankel

Keywords(s):

Category(s): Therapeutic

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